In-vitro evaluation on drug release kinetics and antibacterial activity of dextran modified polyurethane fibrous membrane
| Autor: | P. Sagitha, Nandita Mishra, C.R. Reshmi, Athiyanathil Sujith, Suja P. Sundaran, Anupama Binoy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Blood Platelets
Staphylococcus aureus Curcumin Polyurethanes Microbial Sensitivity Tests 02 engineering and technology Matrix (biology) Biochemistry Mice 03 medical and health sciences chemistry.chemical_compound Platelet Adhesiveness X-Ray Diffraction Structural Biology Spectroscopy Fourier Transform Infrared Animals Humans Molecular Biology 030304 developmental biology Polyurethane 0303 health sciences Dextrans Serum Albumin Bovine 3T3 Cells General Medicine Fibroblasts Hydrogen-Ion Concentration Biodegradation 021001 nanoscience & nanotechnology Anti-Bacterial Agents Drug Liberation Kinetics Steam Membrane Dextran chemistry Thermogravimetry Solvents Wettability Adsorption 0210 nano-technology Wound healing Antibacterial activity Porosity Nuclear chemistry |
| Zdroj: | International Journal of Biological Macromolecules. 126:717-730 |
| ISSN: | 0141-8130 |
| Popis: | pH stimuli drug release nanofibrous membranes of polyurethane/dextran were developed for tailoring of antibacterial wound dressings. Incorporation of dextran in polyurethane (PU) showed increment in hydrophilicity, vapour transmission rate, percentage sorption values, and biodegradability. Dextran also acts as reinforcement filler in PU matrix. Dextran induces a high degree of platelet adhesion and hemostasis potential which is essential for promoting the wound healing process. Moreover, 20 wt% dextran loaded membranes (PU/20D) exhibited enhanced cell proliferation, attachment and viability against 3T3 fibroblasts. Curcumin loaded PU/20 dextran membrane exhibited pH-controlled drug release potency and synergistic antibacterial activity against gram-positive bacteria. It is confirmed that, PU/20D membranes could promote, pH-controlled drug release and synergistic antibacterial activity for a promising wound dressing material. |
| Databáze: | OpenAIRE |
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