Uptake of chylomicron remnants by the liver: further evidence for the modulating role of phospholipids
| Autor: | T J Kotlar, Godfrey S. Getz, Jayme Borensztajn |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Lipoprotein lipase
medicine.medical_specialty Triglyceride Chemistry digestive oral and skin physiology Phospholipid QD415-436 Cell Biology Biochemistry chemistry.chemical_compound Endocrinology Chylomicron remnant In vivo Internal medicine medicine lipids (amino acids peptides and proteins) Hepatic lipase Lymph Chylomicron |
| Zdroj: | Journal of Lipid Research, Vol 29, Iss 8, Pp 1087-1096 (1988) |
| ISSN: | 0022-2275 |
| DOI: | 10.1016/s0022-2275(20)38471-6 |
| Popis: | Rat lymph chylomicrons were treated with rat heparin-releasable hepatic lipase (HL) or with bovine milk lipoprotein lipase (LPL). The ability of the resulting particles to be taken up by the liver in vivo was assessed following their infusion into the portal vein of partially hepatectomized animals. The following observations were made: a) the rate of phospholipid depletion, relative to the rate of triglyceride hydrolysis, induced by HL was two- to threefold higher than that observed for LPL; b) the depletion of at least 57% of phospholipids from the surface of HL-treated chylomicrons caused no major alterations in the apoprotein profile of the particles; c) for the same extent of triglyceride hydrolysis, HL-treated chylomicrons were taken up by liver at a rate significantly higher (P less than 0.005) than LPL-treated particles; d) the liver uptake of HL-treated chylomicrons was competitively inhibited by endogenously generated chylomicron remnants, indicating that these two types of lipoproteins share the same process of recognition and uptake by liver cells. It is concluded that the in vivo changes in phospholipid content, or composition, on the surface of chylomicrons during their transformation into remnants, modulate the differentiation of these two particles by the hepatic remnant receptor. |
| Databáze: | OpenAIRE |
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