Abnormalities of heart rate turbulence and heart rate variability as indicators of increased cardiovascular risk in patients with systemic sclerosis
| Autor: | Bożena Dziankowska-Bartkowiak, Adam Rafał Poliwczak, Katarzyna Dworniak-Pryca, Elżbieta Waszczykowska |
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| Rok vydání: | 2019 |
| Předmět: |
cardiovascular risk
circadian rhythm medicine.medical_specialty systemic sclerosis Physical examination Dermatology Disease Autonomic disorder Heart rate turbulence 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Fibrosis Internal medicine medicine Immunology and Allergy Heart rate variability Circadian rhythm Original Paper medicine.diagnostic_test business.industry heart rate variability autonomic disorders medicine.disease Connective tissue disease heart rate turbulence Cardiology business |
| Zdroj: | Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii |
| ISSN: | 1642-395X |
| DOI: | 10.5114/ada.2019.83134 |
| Popis: | Introduction Systemic sclerosis (SSc) is a connective tissue disease manifested by progressive fibrosis of many internal organs including the cardiovascular system and development of autonomic disorders with sympathetic predominance. These abnormalities can increase cardiovascular mortality. Aim To evaluate heart rate turbulence (HRT) and variability (HRV) parameters (indicator of autonomic imbalance) obtained from 24-hour ECG Holter monitoring, as predictors of the increased cardiovascular risk in patients with scleroderma. Material and methods Thirty-twoscleroderma patients and 30 healthy people were included. After clinical examination, ECG, routine laboratory tests and echocardiography, participants performed 24-hour Holter-ECG at home. For HRT assessment, turbulence onset (To) and turbulence slope (Ts) parameters were used. Both time and frequency domain analysis of HRV was used. The HRV circadian rhythm was also evaluated. Results Time domain: SDNN, SDNN-ix, SDANN and frequency domain: LF, VLF, ULF, NHF, NLF, parameters were lower, while p50NN was higher in SSc as compared to the control group. There was also a loss of the circadian rhythm for r-MSSD and p50NN present in the control group. Abnormal HRT parameters To and/or Ts occurred in the SSc group only. The median value of To = -1.24% and Ts = 11.13 ms/RR did not differ significantly as compared to the control group. Conclusions The study confirmed the presence of HRV disturbances, including HRV circadian rhythm, as it may seem at an early stage of SSc. The HRT disorders may be characterized by the increasing changes with advancing disease. This indicates the presence of autonomic imbalance and an increased cardiovascular risk. |
| Databáze: | OpenAIRE |
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