Median Effective Volume of 0.5% Ropivacaine for Ultrasound-guided Costoclavicular Block
| Autor: | Vishal Kumar, Anu Kewlani, Jeetinder Kaur Makkar, Nidhi Bhatia |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent medicine.drug_class Block (permutation group theory) Young Adult 03 medical and health sciences Motor block 0302 clinical medicine Forearm 030202 anesthesiology medicine Humans Brachial Plexus Ropivacaine Prospective Studies Anesthetics Local Prospective cohort study Ultrasonography Interventional Dose-Response Relationship Drug Local anesthetic business.industry Middle Aged Brachial Plexus Block Ultrasound guided Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Female Effective volume business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Anesthesiology. 134:617-625 |
| ISSN: | 1528-1175 0003-3022 |
| Popis: | Background The median effective dose of ropivacaine required for producing an effective costoclavicular block has not yet been determined. The authors conducted this dose-finding study with the objective of determining the median effective dose of 0.5% ropivacaine required to produce a successful costoclavicular block for surgical anesthesia in 50% of the patients (ED50) as well as the calculated dose required for effective blockade in 95% of the patients (ED95). Methods This single-armed prospective study was conducted on 40 American Society of Anesthesiologists physical status I or II patients, aged 18 to 60 yr, with a body mass index of 18 to 30 kg/m2, scheduled to undergo forearm and hand surgeries under ultrasound-guided costoclavicular block. A volume of 0.5% ropivacaine administered in the costoclavicular space was determined using the sample up-and-down sequential allocation study design of binary response variables. The first patient received a volume of 26 ml of 0.5% ropivacaine. After a successful or unsuccessful block, the volume of local anesthetic was decreased or increased, respectively, by 2 ml in the next patient. Evaluation of sensory and motor block was performed every 5 min for 30 min and graded using a 3-point scale. Surgical anesthesia was considered to be successful if a minimum score of 14 was achieved and the surgeon was able to proceed with surgery without needing to supplement anesthesia. Results The volume of local anesthetic administered ranged from 8 to 26 ml. Centered isotonic regression with a bias-corrected Morris 95% CI derived by bootstrapping showed ED50 of 13.5 ml (95% CI, 11.5 to 15.4 ml) and ED95 of 18.9 ml (95% CI, 17.9 to 27.5 ml). Conclusions A 19-ml dose of 0.5% ropivacaine is likely to produce an effective ultrasound-guided costoclavicular block for providing adequate surgical anesthesia to 95% of the patients. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New |
| Databáze: | OpenAIRE |
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