Nature and severity of lung function abnormalities in extremely pre-term children at 11 years of age
Autor: | Liam Welsh, Janet Stocks, Sooky Lum, Neil Marlow, Enid Hennessy, Jane Kirkby |
---|---|
Rok vydání: | 2010 |
Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Hypersensitivity Immediate Male medicine.medical_specialty Pediatrics Population Nitric Oxide Severity of Illness Index Cohort Studies Internal medicine Diffusing capacity Wheeze medicine Humans Lung Diseases Obstructive Prospective Studies education Child Lung Bronchopulmonary Dysplasia Respiratory Sounds education.field_of_study medicine.diagnostic_test business.industry Infant Newborn Airway obstruction medicine.disease Respiratory Function Tests medicine.anatomical_structure Bronchopulmonary dysplasia Breath Tests Exhaled nitric oxide Cardiology Female medicine.symptom business Infant Premature |
Zdroj: | The European respiratory journal. 37(5) |
ISSN: | 1399-3003 |
Popis: | Advances in neonatal care have resulted in increased survival of children born extremely pre-term (EP). Nevertheless the incidence of bronchopulmonary dysplasia and long-term respiratory morbidity remains high. We investigated the nature of pathophysiological changes at 11 yrs of age to ascertain whether respiratory morbidity in EP children primarily reflects alterations in the lung periphery or more centralised airway function in this population. Spirometry, plethysmography, diffusing capacity, exhaled nitric oxide, multiple-breath washout, skin tests and methacholine challenge were used during laboratory-based assessments in a subgroup of the 1995 EPICure cohort and in controls. Results were obtained in 49 EP and 52 control children. Lung function abnormalities were found in 78% of EP children, with evidence of airway obstruction, ventilation inhomogeneity, gas trapping and airway hyperresponsiveness. Levels of atopy and exhaled nitric oxide were similar between the groups. Prior wheeze was associated with significant reductions in forced flows and volumes. By contrast, abnormalities of the lung periphery appear to be mediated primarily through EP birth per se. The prevalence of lung function abnormalities, which is largely obstructive in nature and likely to have long-term implications, remains high among 11-yr-old children born EP. Spirometry proved an effective means of detecting these persistent abnormalities. |
Databáze: | OpenAIRE |
Externí odkaz: |