Hyperparasitaemia: not a reliable indicator of severity or poor prognosis in falciparum malaria in children in endemic African countries
| Autor: | L.A. Salako, A. Sowunmi, O. Walker |
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| Rok vydání: | 1992 |
| Předmět: |
Drug
Pediatrics medicine.medical_specialty Time Factors media_common.quotation_subject 030231 tropical medicine Parasitemia Disease Hematocrit Severity of Illness Index Antimalarials 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Severity of illness medicine Humans Malaria Falciparum media_common medicine.diagnostic_test biology business.industry Infant Plasmodium falciparum Prognosis medicine.disease biology.organism_classification El Niño Child Preschool Africa Pediatrics Perinatology and Child Health Immunology business Malaria |
| Zdroj: | Annals of Tropical Paediatrics. 12:155-158 |
| ISSN: | 1465-3281 0272-4936 |
| DOI: | 10.1080/02724936.1992.11747561 |
| Popis: | Hyperparasitaemia as an indicator of severity or poor prognosis in falciparum malaria and response to oral antimalarial therapy were evaluated in an outpatient study of 77 consecutive African children from an endemic area. At presentation, clinical illness was graded as mild in 37, moderate in 14 and severe in 26. There was no evidence of renal, hepatic or cerebral complications. Clinical response to oral antimalarial drugs was characterized by rapid and uneventful recovery from illness in all but one patient who required hospital admission with prompt clearance of parasitaemia and fever within 96 hours. It is concluded that greater than 5% parasitaemia may be well tolerated by semi-immune African children. Semi-immune subjects with hyperparasitaemia and no other evidence of severe or complicated disease in an endemic area may well be treated with oral antimalarials providing the infecting strain is fully sensitive to the drug chosen and the drug is rapidly absorbed. |
| Databáze: | OpenAIRE |
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