Childhood lung function and the association with β2-adrenergic receptor haplotypes
| Autor: | Dag E. Undlien, Monica Cheng Munthe-Kaas, Kai-Håkon Carlsen, Karin C. Lødrup Carlsen, Petter Mowinckel, Tale Mæhre Torjussen |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Physiology Single-nucleotide polymorphism Polymorphism Single Nucleotide Tobacco smoke β2 adrenergic receptor Sex Factors Polymorphism (computer science) Forced Expiratory Volume Medicine Humans Prospective Studies Gene–environment interaction Prospective cohort study Child Lung Lung function business.industry Haplotype Infant Newborn Infant General Medicine Pets Asthma Respiratory Function Tests Haplotypes Child Preschool Pediatrics Perinatology and Child Health Immunology Female Tobacco Smoke Pollution Receptors Adrenergic beta-2 business |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 102(7) |
| ISSN: | 1651-2227 |
| Popis: | Aim To determine associations between ADRB2 polymorphisms and lung function through childhood, and possible modification by gender, pet keeping or tobacco smoke. Methods Four ADRB2 single nucleotide polymorphisms (rs1042711, rs1042713, rs1042714 and rs1800888) were genotyped in 953 children from the prospective birth cohort ‘Environment and Childhood Asthma’ study and analysed for association with flow-volume parameters at birth (tidal breathing) and at 10 years of age (maximally forced), stratified by environmental exposures. Results The risk of reduced lung function was reduced in 10-year-old children carrying the most common ADRB2 haplotype (CGGC) (OR 0.45 (95% CI 0.25, 0.82)), whereas there was no association between lung function at birth and ADRB2 haplotypes. Tobacco smoke exposure, gender and pet keeping did not significantly interact with the haplotypes in influencing lung function. Conclusion This study demonstrates a possible protective effect by the ADRB2 haplotype I (CGGC) on reduced FEV1 in 10-year-old children, whereas no ADRB2 geno-/haplotypes were significantly associated with neonatal lung function. The ADRB2 gene thus appears to contribute to lung function development in childhood, independently of smoking, pets and gender. |
| Databáze: | OpenAIRE |
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