Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance
| Autor: | Jörn F. Dopheide, Alexander Vonbank, Gerda Tautermann, Heinz Drexel, Arthur Mader, Christoph H. Saely |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Blood Glucose Male Lifestyle modification medicine.medical_treatment Walking 030204 cardiovascular system & hematology Body Mass Index Low grade inflammation chemistry.chemical_compound 0302 clinical medicine Multidisciplinary Diabetes Patient education Middle Aged Postprandial Period Lipids Postprandial Medicine Female Fat metabolism Adult medicine.medical_specialty Science Body weight Proof of Concept Study Article 03 medical and health sciences Insulin resistance Internal medicine medicine Humans Exercise Triglycerides Dyslipidaemias Inflammation Preventive medicine Triglyceride business.industry Insulin Insulin sensitivity Metabolic diseases medicine.disease 030104 developmental biology Endocrinology Metabolism chemistry Insulin Resistance Sedentary Behavior business Body mass index |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Exercise is a well-established tool for cardiovascular risk reduction. Particularly eccentric exercise, which essentially means walking downwards could favour more people becoming physically active. With the present controlled study, we tested the hypothesis that eccentric exercise can improve insulin sensitivity, triglyceride handling, body mass index, glucose tolerance and inflammation. We allocated 127 healthy sedentary individuals to one of two groups: (i) an active group of 102 individuals walking downwards a predefined route three to five times per week over two months, covering a difference in altitude of 540 m; for the upward route a cable car was used, for which adherence was recorded electronically and (ii) a matched control group of 25 individuals who stayed sedentary. Fasting and postprandial metabolic profiles were obtained at baseline and after two months. Compared to baseline, eccentric exercise significantly improved HOMA insulin resistance (1.94 ± 1.65 vs. 1.71 ± 1.36 (µU−1 ml) × ((mmol/l)−122.5); p = 0.038) and resulted in a decrease in fasting glucose (97 ± 15 vs. 94 ± 9 mg dl−1; p = 0.025) and glucose tolerance (238 ± 50 vs. 217 ± 47 mg dl−1 h−1; p −1 h−1; p = 0.003), whereas triglyceride tolerance remained unchanged in the control group (p = 0.819). Furthermore, body mass index (27.7 ± 4.3 vs. 27.4 ± 4.3 kg m−2; p = 0.003) and C-reactive protein (0.27 ± 0.42 vs. 0.23 ± 0.25 mg dl−1; p = 0.031) were significantly lowered in the eccentric exercise group but not in the control group. Downhill walking, a type of exercise is a promising unusual exercise modality with favorable effects on body mass index, insulin action, on postprandial glucose and triglyceride handling and on C-reactive protein.ClinicalTrials.gov Identifier: NCT00386854. |
| Databáze: | OpenAIRE |
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