Primary Pulmonary Follicular Dendritic Cell Neoplasm: A Case Report and Review of the Literature

Autor:	Krista L, Denning, Peter R, Olson, Richard H, Maley, Veronica R, Flati, Jeffrey L, Myers, Jan F, Silverman
Rok vydání:	2009
Předmět:	Lung Neoplasms Dendritic Cell Sarcoma Follicular Pneumonia General Medicine Middle Aged Immunohistochemistry Pathology and Forensic Medicine Medical Laboratory Technology Radon Biomarkers Tumor Humans Female Diagnostic Errors Pneumonectomy
Zdroj:	Archives of Pathology & Laboratory Medicine. 133:643-647
ISSN:	1543-2165 0003-9985
DOI:	10.5858/133.4.643
Popis:	Follicular dendritic cell tumor (FDCT) is an uncommon neoplasm that typically presents as a slow-growing, painless mass without systemic symptoms. Histologically, FDCT is characterized as a proliferation of spindle to ovoid cells having plump eosinophilic cytoplasm with indistinct borders and nuclei with vesicular or granular chromatin and small distinct nucleoli. The immunohistochemical profile of FDCT includes positive staining for CD21, CD23, CD35, vimentin, fascin, HLA-DR, epithelial membrane antigen, clusterin, and D2-40. Follicular dendritic cell tumor occurs primarily in lymphoid tissue; however, involvement of extranodal sites such as the tonsils, spleen, and gastrointestinal tract has been reported. Lung involvement typically represents metastatic disease with, to our knowledge, only 2 prior cases of extranodal primary FDCT of the lung reported. We report the third case of primary pulmonary FDCT arising in a 64-year-old woman.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1e4ae94604ce8f4eb89756dccf2cbb https://doi.org/10.5858/133.4.643 Zobrazit plný text záznamu Plný text ve formátu PDF