Real-life experience with liver iron concentration R2 MRI measurement in patients with hemoglobinopathies: baseline data from LICNET

Autor:	Filippo Barbiera, Massimiliano Sacco, Maria Caterina Putti, Dario Schembari, Francesco Gioia, Valeria Cigna, Vincenzo Santoro, Maria Rosaria De Ritis, Elisabetta Chiodi, Benedetta Giorgi, Giuseppe Bellisssima, Di Salvo Veronica, Angela Vitrano, Nicola Arcadi, Gesualdo Polizzi, Saveria Campisi, Aldo Filosa, Filippo Cassarà, Crocetta Argento, Vincenzo Caruso, Maria Rita Gamberini, Franco Butera, Alessandra Quota, Giuseppina Calvaruso, Lorenzo Tesé, Aurelio Maggio, Carmelo Fidone, Esther Oliva, Rosario Di Maggio, Laura Mistretta, Rosamaria Rosso, Giovanna Abbate, Calogera Gerardi, Giovanni Giugno, Michele Rizzo, Antonino Giangreco, Maria Fustaneo, Sabrina Bagnato, Valeria Commendatore
Rok vydání:	2016
Předmět:	Adult Male Pediatrics medicine.medical_specialty Liver Iron Concentration Iron Overload Adolescent Iron Thalassemia Ferritin levels Comorbidity Iron Chelating Agents Gastroenterology Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Humans Medicine In patient Child Aged business.industry Deferasirox Alanine Transaminase Hematology General Medicine Baseline data Middle Aged medicine.disease Magnetic Resonance Imaging Hemoglobinopathies Cross-Sectional Studies Hemoglobinopathy Liver chemistry 030220 oncology & carcinogenesis Ferritins Female business Deferiprone Biomarkers 030215 immunology medicine.drug
Zdroj:	European Journal of Haematology. 97:361-370
ISSN:	0902-4441
DOI:	10.1111/ejh.12740
Popis:	Background Real-life data on the use of R2 MRI for the assessment of liver iron concentration (LIC) remain limited. Methods We conducted a cross-sectional analysis on 363 patients (mean age 35.6 yr, 44.1% men) with hemoglobinopathies (204 β-thalassemia major [TM], 102 β-thalassemia intermedia [TI], and 57 sickle cell disease [SCD]) that were evaluated with R2 MRI as part of LICNET, an MRI network of 13 Italian treatment centers. Results The mean LIC was 7.8 mg/g (median: 4.0), with high LIC (>7 mg/g) noted in both transfused (TM, TI 37%; SCD 38%) and non-transfused (TI 20%) patients. Ferritin levels correlated with LIC in both transfused (TM, TI, SCD) and non-transfused (TI) patients (P < 0.001), although lower values predicted high LIC in non-transfused patients (1900 vs. 650 ng/mL in TM vs. non-transfused TI). A correlation between LIC and ALT levels was only noted in HCV-negative patients (rs = 0.316, P < 0.001). The proportion of patients with high LIC was significantly different between iron chelators used (P = 0.023), with the lowest proportion in deferasirox (30%) and highest in deferiprone (53%)-treated patients. Conclusions High LIC values persist in subgroups of patients with hemoglobinopathy, warranting closer monitoring and management optimization, even for non-transfused patients with relatively low ferritin levels.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1dda7227ceff261b41cd8c2a50941d https://doi.org/10.1111/ejh.12740 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.