Effect of interleukin-2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer-bearing mice
| Autor: | Shenglin Ma, Hong Jiang, Wei Wang, Runlei Hu, Xianfu Ke, Dongshan Wei |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Hyperthermia Interleukin 2 Pathology medicine.medical_specialty Necrosis Oncogene Cluster of differentiation General Neuroscience Articles General Medicine Hypothermia Biology medicine.disease General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis medicine Immunohistochemistry General Pharmacology Toxicology and Pharmaceutics medicine.symptom Lung cancer medicine.drug |
| Zdroj: | Biomedical Reports. 4:59-62 |
| ISSN: | 2049-9442 2049-9434 |
| DOI: | 10.3892/br.2015.540 |
| Popis: | The present study aimed to investigate the therapeutic effect of interleukin-2 (IL-2) treatment combined with magnetic fluid hyperthermia (MFH) on Lewis lung cancer-bearing mice. Magnetic fluids were prepared in vitro and directly injected into the tumors in the mice, which were subjected to an alternating magnetic field. The temperature in the tumor reached 43°C and was maintained by controlling the strength of magnetic field for 30 min. Twenty-four hours later, IL-2 was injected directly into the tumors. Mice were divided into four groups: Group I (control), II (MFH), III (IL-2) and IV (IL-2+MFH). The tumor grew gradually in groups II and IV (both P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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