Serum uromodulin is inversely associated with the metabolic syndrome in the KORA F4 study
| Autor: | Jochen Seissler, Cornelia Then, Jürgen E. Scherberich, Annette Peters, Michael Roden, Holger Then, Wolfgang Koenig, Christa Meisinger, Wolfgang Rathmann, Cornelia Huth, Andreas Lechner, Margit Heier, Christian Herder |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
obesity Tamm–Horsfall protein uromodulin Endocrinology Diabetes and Metabolism Population 030232 urology & nephrology Renal function 030204 cardiovascular system & hematology lcsh:Diseases of the endocrine glands. Clinical endocrinology metabolic syndrome 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Internal Medicine Medicine ddc:610 education kidney function serum uromodulin Creatinine education.field_of_study lcsh:RC648-665 biology business.industry Research medicine.disease ddc chemistry Cystatin C biology.protein Metabolic syndrome business sUmod Glomerular hyperfiltration Kidney disease |
| Zdroj: | Endocrine Connections, Vol 8, Iss 10, Pp 1363-1371 (2019) Endocrine Connections |
| ISSN: | 2049-3614 |
| Popis: | Objective Metabolic syndrome and obesity are risk factors for chronic kidney disease. However, early kidney alterations may escape diagnosis in these conditions due to glomerular hyperfiltration. Uromodulin, a glycoprotein exclusively synthesized in tubular cells of the thick ascending limb of Henle's loop, is a novel tissue-specific biomarker for kidney function. In contrast to the commonly used markers creatinine and cystatin C, serum uromodulin does not primarily depend on glomerular filtration. We hypothesized that serum uromodulin is a marker for metabolic syndrome and related components. Design The analyses included 1088 participants of the population-based KORA F4 study aged 62–81 years. Metabolic syndrome was present in 554 participants. After a mean follow-up time of 6.5 years, 621 participants were reevaluated, of which 92 had developed incident metabolic syndrome. Methods The association of serum uromodulin with metabolic syndrome and its components were assessed using multivariable logistic regression models. Results Serum uromodulin was inversely associated with metabolic syndrome after adjustment for sex, age, estimated glomerular filtration rate, physical activity, smoking, alcohol consumption and high-sensitivity C-reactive protein (OR 0.65; 95% CI 0.56–0.76 per standard deviation uromodulin; P Conclusions Serum uromodulin is independently associated with prevalent, but not with incident metabolic syndrome. Low serum uromodulin may indicate a decreased renal reserve in the metabolic syndrome. |
| Databáze: | OpenAIRE |
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