Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension
| Autor: | Hiroaki Matsuoka, Masayoshi Yoshii, Hidehiko Ono, Satoshi Ohta, Masakazu Akashi, Mayumi Saitoh, Megumi Teranishi, Junichi Minami, Kohju Tsukada, Toshihiko Ishimitsu, Masami Ohrui, Hideki Inada |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Aldosterone synthase medicine.medical_specialty Angiotensinogen Essential hypertension Genetic determinism Renin-Angiotensin System Gene Frequency Internal medicine Genotype Internal Medicine medicine Genetic predisposition Cytochrome P-450 CYP11B2 Humans Genetic Predisposition to Disease Allele Gene Genetics Polymorphism Genetic biology business.industry Middle Aged medicine.disease Endocrinology Hypertension biology.protein Female Gene polymorphism business |
| Zdroj: | Journal of Human Hypertension. 16:789-793 |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/sj.jhh.1001484 |
| Popis: | Predispositions to essential hypertension and cardiovascular diseases are possibly associated with gene polymorphisms of the renin-angiotensin system. Gene polymorphisms of angiotensinogen and angiotensin-converting enzyme genes have been suggested to be risk factors for hypertension and myocardial infarction. Concerning the polymorphism of aldosterone synthase (CYP11B2) gene, earlier studies have shown inconsistent results in terms of its relation to hypertension. In the present case-control study, we investigated the association of -344T/C polymorphism in the promoter region of human CYP11B2 gene with genetic predisposition to hypertension. The genotype of -344T/C polymorphism was determined in essential hypertension subjects (n=250) and normotensive subjects (n=221). The distributions of three genotypes (TT, TC, and CC) were significantly different between the hypertensive and the normotensive groups (chi(2)=9.61, P=0.008). Namely, the frequency of C allele was higher in the hypertensive patients than in the normotensive subjects (34.2 vs 26.5%, P=0.010). Our data suggest that the -344C allele of CYP11B2 gene polymorphism is associated with the genetic predisposition to develop essential hypertension. |
| Databáze: | OpenAIRE |
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