A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout
| Autor: | Christoph Joppek, Kim Husemann, Annika Junger, Joachim H. Nagel, Florian Singer, Sophie Yammine, Johannes Port, Martin Kohlhäufl, Philipp Latzin, Philipp Tempel, Ziran Tao |
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| Přispěvatelé: | University of Zurich, Port, Johannes |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Materials science Airflow Sulfur Hexafluoride Biomedical Engineering 2204 Biomedical Engineering 610 Medicine & health 030204 cardiovascular system & hematology Helium Signal Pulmonary Disease Chronic Obstructive 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine TRACER Tidal Volume 1706 Computer Science Applications Humans Child Lung Reproducibility business.industry Respiration Reproducibility of Results Exhalation Washout respiratory system Computer Science Applications respiratory tract diseases Airway Obstruction Sulfur hexafluoride 030228 respiratory system chemistry 10036 Medical Clinic Ultrasonic sensor Pulmonary Ventilation Nuclear medicine business Biomedical engineering |
| Zdroj: | Port, Johannes; Tao, Ziran; Junger, Annika; Joppek, Christoph; Tempel, Philipp; Husemann, Kim; Singer, Florian; Latzin, Philipp; Yammine, Sophie; Nagel, Joachim H; Kohlhäufl, Martin (2017). A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout. Medical & biological engineering & computing, 55(11), pp. 1975-1987. Springer 10.1007/s11517-017-1633-y |
| DOI: | 10.7892/boris.109252 |
| Popis: | For the assessment of small airway diseases, a noninvasive double-tracer gas single-breath washout (DTG-SBW) with sulfur hexafluoride (SF6) and helium (He) as tracer components has been proposed. It is assumed that small airway diseases may produce typical ventilation inhomogeneities which can be detected within one single tidal breath, when using two tracer components. Characteristic parameters calculated from a relative molar mass (MM) signal of the airflow during the washout expiration phase are analyzed. The DTG-SBW signal is acquired by subtracting a reconstructed MM signal without tracer gas from the signal measured with an ultrasonic sensor during in- and exhalation of the double-tracer gas for one tidal breath. In this paper, a simple method to determine the reconstructed MM signal is presented. Measurements on subjects with and without obstructive lung diseases including the small airways have shown high reliability and reproducibility of this method. |
| Databáze: | OpenAIRE |
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