Antidepressant Activity of Alpha-lactalbumin in Chronic Unpredictable Stress Model in Swiss Albino Mice
| Autor: | Ezz El-Din S. Eldenshary, Omar A. H. A. Farid, Rania F. Ahmed, Nadia M. S. Arafa, Gihan F. Asaad, Somaia A. Nada |
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| Rok vydání: | 2020 |
| Předmět: |
Whey protein
lcsh:Medicine 030209 endocrinology & metabolism Pharmacology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine 030212 general & internal medicine Behavior Fluoxetine Depression business.industry lcsh:R Glutamate receptor Neurotransmitters General Medicine Glutathione medicine.disease Alpha-lactalbumin Monoamine neurotransmitter chemistry Oxidative stress Antidepressant Major depressive disorder business medicine.drug |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences, Vol 8, Iss A (2020) Open Access Macedonian Journal of Medical Sciences; Vol. 8 No. A (2020): A-Basic Sciences; 93-99 |
| ISSN: | 1857-9655 |
| DOI: | 10.3889/oamjms.2020.4315 |
| Popis: | BACKGROUND: Major depressive disorder (MDD) is a leading cause for morbidity and mortality. Whey protein components are recently used as functional foods with health benefits. Alpha-lactalbumin (A-LA) is an important component of whey protein. It is a good source of the essential amino acids. OBJECTIVE: This study aimed to examine the possible antidepressant effect of whey protein against MDD induced by chronic unpredictable stress (CUS) in mice. MATERIALS AND METHODS: CUS model is used to induce depression in mice for 24 consecutive days and aimed to evaluate the ability of A-LA compared to fluoxetine to recover depression symptoms. Thirty minutes before exposure to the physical stressor, mice were given A-LA daily in a dose of 75, 150, and 300 mg/kg bwt. RESULTS: The highest dose of A-LA (300 mg/kg bwt.) lessens depression induced in mice. CONCLUSION: This effect might contribute to elevate the level of glutamate and monoamine neurotransmitters, γ-amino-butyric acid inhibition, and enhancement of glutathione in brain tissue. |
| Databáze: | OpenAIRE |
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