Urinary 1-Hydroxypyrene as a Biomarker of Polycyclic Aromatic Hydrocarbons Exposure of Workers on a Contaminated Site
| Autor: | William Dab, Vincent Nedellec, Pascal Empereur-Bissonnet, Fr d ric Dor, Frans J. Jongeneelen, Denis Zmirou, Colin C. Ferguson, Alain Person, Jean-Marie Haguenoer |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Paris medicine.medical_specialty Urinary system Urine Excretion Occupational medicine chemistry.chemical_compound Animal science Occupational Exposure medicine Humans Soil Pollutants Polycyclic Aromatic Hydrocarbons Analysis of Variance Creatinine Pyrenes business.industry Smoking Public Health Environmental and Occupational Health Soil contamination Confidence interval chemistry Biomarker (medicine) Female business Biomarkers |
| Zdroj: | Journal of Occupational and Environmental Medicine. 42:391-397 |
| ISSN: | 1076-2752 |
| Popis: | The aim of the study was to determine the exposure levels of workers to polycyclic aromatic hydrocarbons on gasworks sites by the measurement of urinary 1-hydroxypyrene. Start-shift and end-shift urine samples were taken every day during an entire week (Monday to Friday), once in November and a second time in June. Four groups of workers were selected according to their activity. Increased exposure was only found among volunteers involved in the remediation of a site, 0.16 to 2.31 mumol/mol creatinine in non-smokers. The median of the non-smoker referent group was 0.02 mumol/mol creatinine (95% confidence interval, 0.01 to 0.04). Smokers had greater exposure levels than non-smokers in every group. Within and between variability was around 200%. Assessment of the exposure of persons on contaminated soil is possible, with the condition that the exposed subjects come in direct contact with the soil. |
| Databáze: | OpenAIRE |
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