Body composition and risk of gastric cancer: A population‐based prospective cohort study

Autor: Eddie C. Cheung, Bin Xia, Anran Liu, Jian-Liang Du, Gang Sun, Wenhui Wu, Peng Yun, Changhua Zhang, Yan Tang, You-Zhen Tang, Jinqiu Yuan, Yulong He, Zi-Chong Kuo, Qiangsheng He
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
Cancer Research
medicine.medical_specialty
UK Biobank
fat‐free mass
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Sex Factors
Risk Factors
Stomach Neoplasms
Internal medicine
Weight management
Confidence Intervals
Electric Impedance
cohort study
Medicine
Humans
Radiology
Nuclear Medicine and imaging
Prospective Studies
Registries
Risk factor
Prospective cohort study
Adiposity
Proportional Hazards Models
Original Research
business.industry
Proportional hazards model
gastric cancer
Hazard ratio
Age Factors
Cancer
fat mass
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Body Composition
Female
business
Body mass index
Cancer Prevention
Cohort study
Zdroj: Cancer Medicine, Vol 10, Iss 6, Pp 2164-2174 (2021)
Cancer Medicine
ISSN: 2045-7634
Popis: The recognition of adiposity as a risk factor for gastric cancer is mainly based on traditional anthropometric indices, such as body mass index, which are unable to discriminate between lean and fat mass. We undertook this study to examine body composition and subsequent risk of gastric cancer. This is a prospective analysis of participants free of cancer from the UK Biobank. We measured baseline body composition with electrical bioimpedance analysis and confirmed cancer diagnosis through linkage to cancer and death registries. We evaluated hazard ratios (HRs) and confidence interval (CIs) with COX models adjusting for potential confounders. We documented 326 cases of cancer from 474,929 participants over a median follow‐up of 6.6 years. Both male (HR 1.70, 95% CI 1.01 to 2.89) and female participants (HR 2.47, 95% CI 1.15 to 5.32) in the highest quartile of whole body fat‐free mass were associated with increased risk of gastric cancer as compared with those in the lowest quartile.Whole body fat mass was associated with a decreased risk of gastric cancer (HR per 5‐unit increase 0.86, 95% CI 0.74 to 0.99) in females, but not in males. We concluded that fat‐free mass and fat mass may have different effects on gastric cancer risk. This study provided evidence for individualized weight management for the prevention of gastric cancer.
Based on UK biobank cohort (474,929 participants and 326 cases of gastric cancer), this study found fat‐free mass is assocated with increased risk of gastric cancer in both genders while fat mass is associated with reduced risk of gastric cancer in females. Our results provide new insights into relationships between obesity and gastric cancer, and deliver important clinical and public health messages about healthy body composition beyond BMI.
Databáze: OpenAIRE
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