Body composition and risk of gastric cancer: A population‐based prospective cohort study
Autor: | Eddie C. Cheung, Bin Xia, Anran Liu, Jian-Liang Du, Gang Sun, Wenhui Wu, Peng Yun, Changhua Zhang, Yan Tang, You-Zhen Tang, Jinqiu Yuan, Yulong He, Zi-Chong Kuo, Qiangsheng He |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Male Cancer Research medicine.medical_specialty UK Biobank fat‐free mass lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Sex Factors Risk Factors Stomach Neoplasms Internal medicine Weight management Confidence Intervals Electric Impedance cohort study Medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Registries Risk factor Prospective cohort study Adiposity Proportional Hazards Models Original Research business.industry Proportional hazards model gastric cancer Hazard ratio Age Factors Cancer fat mass Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology Oncology 030220 oncology & carcinogenesis Body Composition Female business Body mass index Cancer Prevention Cohort study |
Zdroj: | Cancer Medicine, Vol 10, Iss 6, Pp 2164-2174 (2021) Cancer Medicine |
ISSN: | 2045-7634 |
Popis: | The recognition of adiposity as a risk factor for gastric cancer is mainly based on traditional anthropometric indices, such as body mass index, which are unable to discriminate between lean and fat mass. We undertook this study to examine body composition and subsequent risk of gastric cancer. This is a prospective analysis of participants free of cancer from the UK Biobank. We measured baseline body composition with electrical bioimpedance analysis and confirmed cancer diagnosis through linkage to cancer and death registries. We evaluated hazard ratios (HRs) and confidence interval (CIs) with COX models adjusting for potential confounders. We documented 326 cases of cancer from 474,929 participants over a median follow‐up of 6.6 years. Both male (HR 1.70, 95% CI 1.01 to 2.89) and female participants (HR 2.47, 95% CI 1.15 to 5.32) in the highest quartile of whole body fat‐free mass were associated with increased risk of gastric cancer as compared with those in the lowest quartile.Whole body fat mass was associated with a decreased risk of gastric cancer (HR per 5‐unit increase 0.86, 95% CI 0.74 to 0.99) in females, but not in males. We concluded that fat‐free mass and fat mass may have different effects on gastric cancer risk. This study provided evidence for individualized weight management for the prevention of gastric cancer. Based on UK biobank cohort (474,929 participants and 326 cases of gastric cancer), this study found fat‐free mass is assocated with increased risk of gastric cancer in both genders while fat mass is associated with reduced risk of gastric cancer in females. Our results provide new insights into relationships between obesity and gastric cancer, and deliver important clinical and public health messages about healthy body composition beyond BMI. |
Databáze: | OpenAIRE |
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