Automated actuation of nasal spray products: determination and comparison of adult and pediatric settings
| Autor: | Diane V. Doughty, Richard N. Dalby, Mary E. Bollinger, Anupama Kewalramani, C. Vibbert |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Computer science medicine.medical_treatment Anti-Inflammatory Agents Pharmaceutical Science parasitic diseases Drug Discovery medicine Pressure Humans Displacement (orthopedic surgery) Child Administration Intranasal Pharmacology Aerosols Organic Chemistry Rhinitis Allergic Seasonal Nasal Sprays Middle Aged Compression (physics) Surgery Androstadienes Nasal spray Fluticasone Actuator Biomedical engineering |
| Zdroj: | Drug development and industrial pharmacy. 37(3) |
| ISSN: | 1520-5762 |
| Popis: | To determine and compare patient-relevant settings for automated nasal spray actuation stations from adult and pediatric hand data.Twenty adults and 20 pediatric participants were asked to spray Flonase(®) Nasal Spray six times in a Hand Actuation Monitor, which records force and displacement data in 5-ms increments. Settings for force- and velocity-controlled actuation stations were determined from the data using a predefined set of calculations.For force-controlled settings, hand spraying by children resulted in lower actuation forces, and longer force rise, hold and fall times. Pediatric velocity-controlled actuator settings were lower for travel, compression velocity, and release velocity compared with adults. The pediatric spray weight recorded during hand spraying was significantly lower than the spray weight generated by adult participants. Adult participants were able to generate full sprays with each attempt, whereas 11 out of 120 actuations performed by pediatric participants resulted in partial and 'no spray' events. No differences in spray weight were detected in participants who chose to actuate the nasal spray using both hands.A predefined set of calculations was used to determine patient-relevant settings from force and displacement hand data for force- and velocity-controlled automated actuation stations. This study determined and quantified, for the first time, the differences in hand spraying between adults and children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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