Differential Regional Distribution of Juxtacortical White Matter Signal Abnormalities in Aging and Alzheimer’s Disease
| Autor: | Douglas N. Greve, Bruce Fischl, Jean C. Augustinack, David H. Salat, Emily R. Lindemer |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Disease Normal aging Article Healthy Aging White matter 03 medical and health sciences 0302 clinical medicine Neuroimaging Alzheimer Disease Internal medicine medicine Humans Distribution (pharmacology) Pathological Aged medicine.diagnostic_test business.industry General Neuroscience Brain Magnetic resonance imaging Organ Size General Medicine Magnetic Resonance Imaging White Matter Hyperintensity Psychiatry and Mental health Clinical Psychology 030104 developmental biology medicine.anatomical_structure Cardiology Female Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 57:293-303 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background White matter signal abnormalities (WMSA) (also known as 'hyperintensities') on MRI are commonly seen in normal aging and increases have been noted in Alzheimer's disease (AD), but whether there is a spatial specificity to these increases is unknown. Objective To discern whether or not there is a spatial pattern of WMSA in the brains of individuals with AD that differs from those who exhibit cognitively healthy aging. Method Structural MRI data from the Alzheimer's Disease Neuroimaging Initiative public database were used to quantify WMSA in 35 regions of interest (ROIs). Regional measures were compared between cognitively healthy older controls (OC; n = 107) and individuals with a clinical diagnosis of AD (n = 127). Regional WMSA volume was also assessed in individuals with mild cognitive impairment (MCI; n = 74) who were 6, 12, and 24 months away from AD conversion. Results WMSA volume was significantly greater in AD compared to OC in 24 out of 35 ROIs after controlling for age, and nine were significantly higher after normalizing for total WMSA. Regions with greater WMSA volume in AD included rostral frontal, inferior temporal, and inferior parietal WM. In MCI, frontal and temporal regions demonstrated significantly greater WMSA volume with decreasing time-to-AD-conversion. Discussion Individuals with AD have greater regional volume of WMSA compared to OC regardless of age or total WMSA volume. Accumulation of regional WMSA is linked to time to AD conversion in individuals with MCI. These findings indicate WMSA is an important pathological component of AD development. |
| Databáze: | OpenAIRE |
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