Myeloid marker expression on antiviral CD8+ T cells following an acute virus infection
| Autor: | Sungyoo Cho, Tonya J. Roberts, Yinling Lin, Randy R. Brutkiewicz, Venkataraman Sriram |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Myeloid Immunology Population chemical and pharmacologic phenomena CD8-Positive T-Lymphocytes Lymphocytic Choriomeningitis Biology Lymphocytic choriomeningitis Virus Mice medicine Animals Immunology and Allergy Cytotoxic T cell education Mice Inbred BALB C education.field_of_study CD11b Antigen hemic and immune systems Dendritic cell medicine.disease Antigens Differentiation Virology Molecular biology CD11c Antigen Mice Inbred C57BL CTL medicine.anatomical_structure Acute Disease Female CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | European Journal of Immunology. 33:2736-2743 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.200324087 |
| Popis: | CD11b, CD11c, and F4/80 are normally used to define dendritic cell and/or macrophage populations. In this study, the expression of all three markers was observed on CD8(+) T cells following infection of mice with several distinct viruses. Using lymphocytic choriomeningitis virus as a model virus, it was found that relatively more CD11b(+)CD8(+) and CD11c(+)CD8(+) T cells were present in the periphery than in primary lymphoid organs; in contrast, the F4/80(+)CD8(+) T cell population was more prevalent in the spleen. All three myeloid markers were detected on virus-specific CTL. The expression of CD11b and CD11c on CD8(+) T cells correlated with their level of CTL activity, whereas the F4/80(+)CD8(+) T cell population increased after the peak of the CTL response but did not have higher CTL activity. These data suggest that there is a differential induction of CD11b, CD11c, and F4/80 on virus-specific CD8(+) T cells following an acute virus infection. |
| Databáze: | OpenAIRE |
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