Dying to protect: cell death and the control of T-cell homeostasis
| Autor: | Kun-Po Li, Sharmila Shanmuganad, David A. Hildeman, Kaitlin R. Carroll, Jonathan D. Katz, Michael B. Jordan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Graft Rejection
0301 basic medicine Programmed cell death Cell Survival T-Lymphocytes Immunology chemical and pharmacologic phenomena Major histocompatibility complex medicine.disease_cause Article Autoimmune Diseases Autoimmunity 03 medical and health sciences 0302 clinical medicine Immune system medicine Animals Homeostasis Humans Immunology and Allergy Receptor Transplantation Cell Death biology Vaccination Immunologic Deficiency Syndromes Acquired immune system 030104 developmental biology biology.protein Immunotherapy 030215 immunology |
| Zdroj: | Immunological Reviews. 277:21-43 |
| ISSN: | 0105-2896 |
| Popis: | T cells play a critical role in immune responses as they specifically recognize peptide/MHC complexes with their T cell receptors (TCRs) and initiate adaptive immune responses. While T cells are critical for performing appropriate effector functions and maintaining immune memory, they also can cause autoimmunity or neoplasia if misdirected or dysregulated. Thus, T cells must be tightly regulated from their development onward. Maintenance of appropriate T cell homeostasis is essential to promote protective immunity and limit autoimmunity and neoplasia. This review will focus on the role of cell death in maintenance of T cell homeostasis and outline novel therapeutic strategies tailored to manipulate cell death to limit T cell survival (eg autoimmunity and transplantation) or enhance T cell survival (eg vaccination, immune-deficiency). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|