Reactivity of the monoclonal antibody RFB1 in chronic B-cell leukaemias
| Autor: | M. Bodger, D. Catovsky, J. V. Melo |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Rosette Formation
Lymphoma medicine.drug_class Chronic lymphocytic leukemia Cell Monoclonal antibody hemic and lymphatic diseases medicine Humans Reactivity (chemistry) B cell B-Lymphocytes Leukemia Hairy Cell biology Chemistry Antibodies Monoclonal Cell Differentiation Hematology medicine.disease Molecular biology Leukemia Lymphoid medicine.anatomical_structure Immunology biology.protein Antibody Differential diagnosis |
| Zdroj: | Scandinavian Journal of Haematology. 32:417-422 |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1984.tb00698.x |
| Popis: | The monoclonal antibody RFB1, which reacts with early haemopoietic precursors in human bone marrow and peripheral T-lymphocytes, but not with pre-B cells and mature peripheral blood and marrow B lymphocytes, was tested in blood from 60 patients with chronic B cell leukaemias. All 37 cases of B chronic lymphocytic leukaemia (B-CLL) and 9 of hairy cell leukaemia (HCL) were positive. The antibody showed particularly strong reaction in HCL. On the other hand, RFB1 did not react with peripheral blood and B lymphocytes from 9 patients with non-Hodgkin lymphoma (NHL) in leukaemic phase and was negative or weakly expressed in 5 with prolymphocytic leukaemia (B-PLL). These findings may be significant for investigations on the cell origin of B-CLL and HCL. The reactivity of RFB1 was different from that of two anti-T1 monoclonal antibodies. The combined use of these reagents gave distinct patterns in B-CLL (RFB1+, T1+), HCL (RFB1++, T1-) and NHL and B-PLL (RFB1-/+/-, Tl-/+), suggesting they may be of value in the differential diagnosis of these B-lymphoproliferative disorders. |
| Databáze: | OpenAIRE |
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