Possible Association of Elevated Plasma Levels of Growth Arrest-Specific Protein 6 and the Soluble Form of Tyrosine Kinase Receptor Axl with Low Hepatitis C Viral Load in Patients with Type 2 Diabetes Mellitus
| Autor: | Sylvana N. Gaber, Ahmed A. Gomaa, Mahmoud A F Khalil, Essam A. Hassan, Mohamed Mashahit, Rasha H. Bassyouni, El Shaimaa Gomaa Ali |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine endocrine system diseases Hepatitis C virus Immunology medicine.disease_cause Receptor tyrosine kinase Virus 03 medical and health sciences 0302 clinical medicine Proto-Oncogene Proteins Virology Diabetes mellitus Humans Medicine In patient Aged biology business.industry GAS6 Receptor Protein-Tyrosine Kinases nutritional and metabolic diseases Type 2 Diabetes Mellitus Plasma levels Hepatitis C Chronic Middle Aged Viral Load medicine.disease Axl Receptor Tyrosine Kinase 030104 developmental biology Diabetes Mellitus Type 2 biology.protein Intercellular Signaling Peptides and Proteins Molecular Medicine Female 030211 gastroenterology & hepatology business Biomarkers |
| Zdroj: | Viral Immunology. 33:105-111 |
| ISSN: | 1557-8976 0882-8245 |
| DOI: | 10.1089/vim.2019.0127 |
| Popis: | This study aimed to investigate the plasma levels of Gas6 and soluble Axl (sAxl) in patients with chronic hepatitis C virus (HCV) infection with and without type 2 diabetes mellitus (T2DM). The study involved four groups; 50 patients with chronic HCV, 50 patients with T2DM, 50 patients with chronic HCV and T2DM, and 31 age- and sex-matched healthy controls. T2DM was diagnosed according to American Diabetes Association criteria, HCV antibodies were detected by enzyme-linked immunosorbent assays (ELISA) and confirmed by real-time-polymerase chain reaction. Plasma Gas6 and sAxl levels were assayed in all groups by ELISA. Significant low levels of GAS 6 in HCV/T2DM group versus HCV group were detected (7.92 ± 5.18 vs. 16.09 ± 7.36, respectively |
| Databáze: | OpenAIRE |
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