Visceral obesity attenuates the effect of the hepatic lipase -514CT polymorphism on plasma HDL-cholesterol levels in French-Canadian men
| Autor: | Marie-Eve Paradis, Jean-Pierre Després, Daniel Gaudet, Benoît Lamarche, Isabelle Miller-Felix, Marie-Claude Vohl, Julie St-Pierre, Jean Bergeron |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Canada Waist Apolipoprotein B Genotype Endocrinology Diabetes and Metabolism Lipoproteins Adipose tissue Single-nucleotide polymorphism Biochemistry Body Mass Index chemistry.chemical_compound Endocrinology Gene Frequency Internal medicine Genetics medicine Humans Obesity Molecular Biology Abdominal obesity Alleles Analysis of Variance Polymorphism Genetic biology Cholesterol Cholesterol HDL Lipase Middle Aged Lipids Viscera chemistry Liver biology.protein lipids (amino acids peptides and proteins) Hepatic lipase France medicine.symptom |
| Zdroj: | Molecular genetics and metabolism. 78(1) |
| ISSN: | 1096-7192 |
| Popis: | The dyslipidemic state of visceral obesity is characterized by increased plasma triglyceride (TG) levels, low HDL-cholesterol concentrations and alterations in LDL composition and concentration. A functional, non-coding −514C>T single nucleotide polymorphism (SNP) of the hepatic lipase gene (LIPC) has been related to variation in HDL-cholesterol concentrations. Objectives: To investigate the hypotheses that the LIPC −514C>T polymorphism may be associated with a deteriorated lipoprotein-lipid profile and that environmental factor, such as abdominal obesity, alters this association. Methods: A total of 235 French-Canadian men from the greater Quebec City area were assigned into three groups on the basis of their LIPC −514C>T SNP, including 149 CC homozygotes, 75 CT heterozygotes, and 11 TT homozygotes. Results: In the present study, the highest values of BMI, waist circumference, and accumulation of visceral adipose tissue (VAT) were observed among TT homozygotes (pT polymorphism on plasma HDL2-cholesterol levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect