Hematopoietic stem cells and retroviral infection
| Autor: | Prabal Banerjee, Gerold Feuer, Lindsey B. Crawford, Elizabeth Samuelson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Lymphoma Review 03 medical and health sciences 0302 clinical medicine Cancer stem cell Virology medicine Humans Progenitor cell 030304 developmental biology 0303 health sciences Leukemia biology Hematopoietic stem cell medicine.disease Hematopoietic Stem Cells 3. Good health Haematopoiesis Infectious Diseases medicine.anatomical_structure Retroviridae 030220 oncology & carcinogenesis Immunology biology.protein Stem cell Antibody lcsh:RC581-607 Retroviridae Infections |
| Zdroj: | Retrovirology, Vol 7, Iss 1, p 8 (2010) Retrovirology |
| ISSN: | 1742-4690 |
| Popis: | Retroviral induced malignancies serve as ideal models to help us better understand the molecular mechanisms associated with the initiation and progression of leukemogenesis. Numerous retroviruses including AEV, FLV, M-MuLV and HTLV-1 have the ability to infect hematopoietic stem and progenitor cells, resulting in the deregulation of normal hematopoiesis and the development of leukemia/lymphoma. Research over the last few decades has elucidated similarities between retroviral-induced leukemogenesis, initiated by deregulation of innate hematopoietic stem cell traits, and the cancer stem cell hypothesis. Ongoing research in some of these models may provide a better understanding of the processes of normal hematopoiesis and cancer stem cells. Research on retroviral induced leukemias and lymphomas may identify the molecular events which trigger the initial cellular transformation and subsequent maintenance of hematologic malignancies, including the generation of cancer stem cells. This review focuses on the role of retroviral infection in hematopoietic stem cells and the initiation, maintenance and progression of hematological malignancies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink