The effect of plant sterols on serum triglyceride concentrations is dependent on baseline concentrations: a pooled analysis of 12 randomised controlled trials
| Autor: | Henk C. M. van der Knaap, Isabelle Demonty, Elke A. Trautwein, Rouyanne T. Ras, Linsie Meijer, Johanna M. Geleijnse, Peter L. Zock |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Nutrition and Disease cardiovascular-disease Medicine (miscellaneous) Blood lipids phytosterol intake Plant sterols Pooled analysis chemistry.chemical_compound mildly hypercholesterolemic subjects Voeding en Ziekte Internal medicine medicine Diet and lifestyle Humans ldl-cholesterol concentrations plasma-lipids Triglycerides VLAG clinical-trials Randomized Controlled Trials as Topic Global Nutrition Wereldvoeding enriched spread fat spreads Nutrition and Dietetics Triglyceride Cholesterol business.industry Anticholesteremic Agents Cholesterol HDL Phytosterols density-lipoprotein cholesterol Original Contribution Cholesterol LDL Clinical trial Endocrinology chemistry Meta-analysis lipids (amino acids peptides and proteins) diet business Lipoprotein |
| Zdroj: | European Journal of Nutrition European Journal of Nutrition, 52(1), 153-160 European Journal of Nutrition 52 (2013) 1 |
| ISSN: | 1436-6215 1436-6207 |
| Popis: | Purpose - Plant sterols (PS) are well known for their low-density lipoprotein cholesterol-lowering effect. Until recently, they were believed to have little or no impact on blood triglycerides (TG). However, studies taken individually were possibly lacking statistical power to detect modest TG decreases. This study was performed to quantify the TG-lowering effect of PS by pooling individual subject data from 12 randomised controlled trials that investigated the effects of PS on blood lipids. Methods - The main outcome variable was the control-adjusted PS effect on relative (%) and absolute (mmol/L) changes in TG. The relative and absolute changes in high-density lipoprotein cholesterol (HDL-C) were also assessed. Differences in changes of serum lipid concentrations between PS and control treatments were estimated by an ANCOVA using a random effect model which included PS intake (active or control), study and predefined subject characteristics. Results - The twelve randomised controlled trials included in total 935 hypercholesterolaemic subjects not preselected based on their baseline TG concentrations. In most studies, the PS dose ranged between 1.6 and 2.5 g/day. PS intake significantly lowered serum TG by 6.0% (95% CI: -10.7, -1.2) or 0.12 mmol/L (95% CI: -0.20, -0.04). No significant interaction was observed between PS intake and baseline TG concentrations on relative changes, but, on absolute changes, interaction was significant with larger TG decreases observed with higher TG concentrations at baseline. No effects were observed on HDL-C concentrations. Conclusions - These results show that PS exert a modest TG-lowering effect which is dependent on baseline concentrations. |
| Databáze: | OpenAIRE |
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