Expression of cancer-associated genes in prostate tumors at mRNA and protein levels

Autor: Vladimir I. Kashuba, G. V. Gerashchenko, E. E. Rosenberg, O. V. Grygoruk, Yu. M. Bondarenko, Elena Kashuba
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Popis: Aim. To analyze an expression pattern of the cancer-associated genes in prostate tumors at mRNA and protein levels and find putative association between the expression of these genes and the genes, controlling epithelial to mesenchymal cell transition (EMT), the markers of prostate cancer and stromal elements. Methods. Relative expression of genes was assessed by a quantitative PCR in 29 prostate cancer tissue samples (T) of different Gleason score (GS) and tumor stage, 29 paired conventionally normal prostate tissue (CNT) samples and in 14 samples of prostate adenomas (A). Immunohistochemistry (IHC) was used to assess protein expression. Results. We found significant differences (p
Databáze: OpenAIRE