Concurrent elevations of VEGF, osteopontin and MCP-1 serum levels are independent predictors of survival in patients with Diffuse large B- Cell lymphoma
| Autor: | Elizabeta Fišić, Antica Duletić-Načinović, Irena Seili-Bekafigo, Vedrana Gačić, Marta Žuvić-Butorac, Ksenija Lučin, Nives Jonjić, Toni Valković |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences medicine.medical_specialty diffuse osteopontin Pilot Projects lymphoma vascular endothelial growth factor a 03 medical and health sciences chemistry.chemical_compound large b-cell 0302 clinical medicine International Prognostic Index stomatognathic system Chemoimmunotherapy hemic and lymphatic diseases Internal medicine chemokine ccl2 medicine Humans Osteopontin prognosis Univariate analysis biology business.industry BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti Hematology General Medicine medicine.disease Lymphoma Vascular endothelial growth factor 030104 developmental biology chemistry B symptoms 030220 oncology & carcinogenesis Cancer research biology.protein Lymphoma Large B-Cell Diffuse medicine.symptom business Diffuse large B-cell lymphoma |
| Zdroj: | Acta Haematologica Volume 136 Issue 1 |
| ISSN: | 0001-5792 1421-9662 |
| Popis: | Background: Diffuse large B-cell lymphomas (DLBCL) are heterogeneous diseases, and the identification of additional DLBCL risk factors is especially important. Methods: In this pilot study, we determined pretreatment serum levels of vascular endothelial growth factor (VEGF), osteopontin (OPN) and macrophage chemotactic protein-1 (MCP-1) in 67 newly diagnosed DLBCL patients before treatment with standard chemoimmunotherapy and in 30 healthy persons. Results: Serum levels of all three cytokines were significantly elevated in untreated patients compared to controls. VEGF and OPN concentrations were higher in patients with advanced Ann Arbor stage, B symptoms, Eastern Cooperative Oncology Group score ≥2, International Prognostic Index (IPI) ≥3 and partial/no remission. A high MCP-1 level was associated with advanced stage, increased IPI and bone marrow infiltration. In univariate analysis, elevated OPN and VEGF, and concurrent elevation of all three biomarkers, were identified as significant predictors of poor survival. Multivariate Cox analysis revealed that elevated OPN combined with elevated VEGF levels was one of the best parameter subsets predicting poorest survival. Conclusion: According to our preliminary results, serum levels of VEGF and OPN before treatment predict response to therapy and survival after chemoimmunotherapy, and may help to further stratify DLBCL patients into risk groups. |
| Databáze: | OpenAIRE |
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