Epidemiology and antimicrobial susceptibility of invasive Escherichia coli infection in neonates from 2012 to 2019 in Xiamen, China
| Autor: | Yao Zhu, Ji-Dong Lai, Xinzhu Lin, Li-Xia Tang |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine China medicine.medical_specialty 030106 microbiology Drug resistance Chorioamnionitis Gastroenterology lcsh:Infectious and parasitic diseases Sepsis 03 medical and health sciences 0302 clinical medicine Medical microbiology Pregnancy Ampicillin Internal medicine Drug Resistance Bacterial Escherichia coli medicine Humans lcsh:RC109-216 030212 general & internal medicine Pregnancy Complications Infectious Escherichia coli Infections Cross Infection Clinical characteristics Late-onset infection business.industry Incidence Incidence (epidemiology) Infant Newborn Newborn medicine.disease Early-onset infection Anti-Bacterial Agents Pneumonia Infectious Diseases Female Neonatal Sepsis business Research Article Piperacillin medicine.drug |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021) |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/s12879-021-05981-4 |
| Popis: | Background Escherichia coli (E. coli) is one of the important causative pathogens of neonatal invasive infection. The epidemiological and clinical profile of invasive E. coli infection in Chinese newborns is not well characterized. Methods Ninety-four infants with invasive E. coli infection were categorized into E. coli early onset disease (EOD) group (onset ≤72 h after birth) (n = 46) and E. coli late onset disease (LOD) group (onset > 72 h) (n = 48). We compared and analyzed the clinical characteristics and drug sensitivity profile of early-onset and late-onset E. coli invasive infection in neonates. Results The incidence of E. coli-EOD and E.coli-LOD was 0.45/1000 live births (LBs) and 0.47/1000 LBs, respectively. The incidence of gestational diabetes mellitus, perinatal fever, urinary tract infection, chorioamnionitis, and positive E. coli culture among mothers in the E. coli-EOD group were significantly higher than that in E. coli-LOD group. The incidence of premature birth, low-birth-weight, nosocomial infection, and hospitalization time were significantly higher in the E. coli-LOD group. The main disease in E. coli-EOD group was pneumonia (main clinical manifestation: dyspnea). The main disease in E. coli-LOD group was sepsis (main clinical manifestation: fever). The sensitivity rates of E. coli strains to ampicillin and piperacillin were low (25.00–28.79%); sensitivity to cephalosporins was also low except ceftazidime (lowest sensitivity rate: 57.14%). Sensitivity to compound preparations containing β-lactamase inhibitors was high, even for extended spectrum β-lactamase-positive strains (nearly 100%). Conclusion E. coli is an important cause of invasive infection of newborns in Xiamen, China. E. coli-EOD was largely attributable to perinatal factors, while E. coli-LOD was largely related to nosocomial infection. Compound preparations containing β-lactamase inhibitor or carbapenem antibiotics should be preferred for neonatal invasive infection by E. coli. |
| Databáze: | OpenAIRE |
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