Continuous peritoneal dialysis in acute experimental pancreatitis in dogs. Effect of aprotinin in the dialysate medium
| Autor: | Italo Vantini, Sergio Vesentini, Giorgio Cavallini, F. Orcalli, Claudio Bassi, Massimo Falconi, Gianfranco Maffezzoli, G. F. Briani, Paolo Pederzoli |
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| Přispěvatelé: | C., Bassi, G., Briani, S., Vesentini, F., Orcalli, Falconi, Massimo, I., Vantini, G., Cavallini, G., Maffezzoli, P., Pederzoli |
| Rok vydání: | 1989 |
| Předmět: |
Acute necrotizing pancreatitis
medicine.medical_specialty medicine.medical_treatment Beagle Gastroenterology Peritoneal dialysis Necrosis Endocrinology Aprotinin Dogs Internal medicine Medicine Animals Edema Pancreatic duct Inflammation business.industry Thrombosis medicine.disease Trypsin Fibrosis Hemodialysis Solutions Surgery medicine.anatomical_structure Oncology Pancreatitis Acute Disease Acute pancreatitis business Peritoneal Dialysis medicine.drug |
| Zdroj: | International journal of pancreatology : official journal of the International Association of Pancreatology. 5(1) |
| ISSN: | 0169-4197 |
| Popis: | In 27 beagle dogs, acute necrotizing pancreatitis was induced by retrograde injection of autologous bile and trypsin into the main pancreatic duct. Animals were randomly assigned to the following treatments: group 1--(9 dogs) aprotinin 600,000 KIU/d by i.v. route; group 2--(9 dogs) peritoneal dialysis for 6 d plus 500,000 KIU/L of aprotinin in the dialysate fluid; group 3--(9 dogs) peritoneal dialysis without aprotinin in the dialysate fluid. All dogs of the group 1 died within 16 h following the induction of pancreatitis and extensive necrotizing and hemorrhagic changes were seen in the pancreatic and peripancreatic areas. Six dogs of the group 2 survived and no necrotizing changes were observed 30 or 50 d after the induction of pancreatitis. Three dogs of the group 3 survived, but slight necrotizing lesions were found at the autopsy. The survival rate was higher in dogs with peritoneal lavage (p = 0.0129) or with peritoneal lavage plus aprotinin (p less than 0.0001) than in those receiving i.v. aprotinin, indicating that the latter treatment has no beneficiary effect on the course of acute pancreatitis. |
| Databáze: | OpenAIRE |
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