Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo
| Autor: | Farouc A. Jaffer, Roman Shubochkin, Jason R. McCarthy, Jin Won Kim, Brett E. Bouma, Hongki Yoo, Eman Namati, Theodore F. Morse, Guillermo J. Tearney, Vasilis Ntziachristos, Milen Shishkov |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Fluorescence-lifetime imaging microscopy Materials science Catheters Myocardial Infarction Context (language use) Coronary Artery Disease 030204 cardiovascular system & hematology 01 natural sciences General Biochemistry Genetics and Molecular Biology Article 010309 optics 03 medical and health sciences 0302 clinical medicine Optical coherence tomography In vivo 0103 physical sciences Microscopy medicine Intra arterial Animals Humans Inflammation Spectroscopy Near-Infrared medicine.diagnostic_test General Medicine Arteries Plaque Atherosclerotic 3. Good health Molecular Imaging Catheter Radiology Rabbits Molecular imaging Biomedical engineering |
| Zdroj: | Nature medicine |
| ISSN: | 1546-170X 1078-8956 |
| Popis: | Advancing our understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression, and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this novel catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing, and for identifying high-risk biological and structural coronary arterial plaques in vivo. |
| Databáze: | OpenAIRE |
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