Adipose triglyceride lipase promotes the proliferation of colorectal cancer cells via enhancing the lipolytic pathway
| Autor: | Honghai Hong, Zhaofan Luo, Shaotuan Deng, Wentao Li, Caiqi Ma, Haofan Yin, Chuanghua Luo, Weijia Lin, Laiming Mo |
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| Rok vydání: | 2021 |
| Předmět: |
lipolytic
Male 0301 basic medicine adipose triglyceride lipase Colorectal cancer proliferation Lipolysis Mice Nude colorectal cancer Apoptosis Biology Mice 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor Tumor Cells Cultured medicine Animals Humans neoplasms Carcinogen Cell Proliferation Mice Inbred BALB C Gene knockdown Oncogene Cell growth Lipid metabolism Original Articles Lipase Cell Biology Middle Aged Lipid Metabolism Prognosis medicine.disease Xenograft Model Antitumor Assays digestive system diseases Gene Expression Regulation Neoplastic Survival Rate 030104 developmental biology 030220 oncology & carcinogenesis Adipose triglyceride lipase Cancer research Molecular Medicine Original Article Female Colorectal Neoplasms |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| DOI: | 10.1111/jcmm.16349 |
| Popis: | Abnormal lipid metabolism is the sign of tumour cells. Previous researches have revealed that the lipolytic pathway may contribute to the progression of colorectal cancer (CRC). However, adipose triglyceride lipase (ATGL) role in CRC cells remains unclear. Here, we find that elevated ATGL positively correlates with CRC clinical stages and negatively associates with overall survival. Overexpression of ATGL significantly promotes CRC cell proliferation, while knockdown of ATGL inhibits the proliferation and promotes the apoptosis of CRC cells in vitro. Moreover, in vivo experiments, ATGL promotes the growth of CRC cells. Mechanistically, ATGL enhances the carcinogenic function of CRC cells via promoting sphingolipid metabolism and CoA biosynthesis pathway‐related gene levels by degrading triglycerides, which provides adequate nutrition for the progression of CRC. Our researches clarify for the first time that ATGL is a novel oncogene in CRC and may provide an important prognostic factor and therapeutic target for CRC. |
| Databáze: | OpenAIRE |
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