Efficacy and safety of insulin degludec U100 and insulin glargine U100 in combination with meal-time bolus insulin in hospitalized patients with type 2 diabetes: an open-label, randomized controlled study
| Autor: | Kenichiro Takahashi, Yasuo Terauchi, Kazuaki Kadonosono, Yoshihisa Okamoto, Haruka Tamura, Erina Shigematsu, Tatsuro Takano, Tadashi Yamakawa, Jo Nagakura, Jun Suzuki, Rika Sakamoto, Minori Shinoda, Mari S. Oba |
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| Rok vydání: | 2019 |
| Předmět: |
Insulin degludec
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Insulin Glargine 030209 endocrinology & metabolism Type 2 diabetes Hypoglycemia Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine Endocrinology Randomized controlled trial law Internal medicine medicine Humans Hypoglycemic Agents Insulin Meals Glycemic Aged business.industry Insulin glargine Fasting Middle Aged medicine.disease Postprandial Period Hospitalization Insulin Long-Acting Postprandial Treatment Outcome Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Female business medicine.drug |
| Zdroj: | Endocrine journal. 66(11) |
| ISSN: | 1348-4540 |
| Popis: | The short-term efficacy and safety of insulin degludec U100 (IDeg) in patients with type 2 diabetes have not been reported widely. We compared insulin IDeg and insulin glargine U100 (IGla) for glycemic control and glucose variability in hospitalized patients with type 2 diabetes. In an open-label, multicenter, randomized controlled trial, 74 patients were randomly assigned to either the IDeg (36 patients) or IGla (38 patients) group and were administered with basal-bolus therapy during hospitalization. Following the start of the treatment, on day 11, glucose variability was assessed by continuous glucose monitoring. A fasting blood glucose level of 110 mg/dL and 2-hour postprandial blood glucose level of 180 mg/dL throughout at least one day during the observation period were achieved in 31.3% (10/32) and 30.6% (11/36) of the patients in the IDeg and IGla groups, respectively. The 6-point self-monitoring of blood glucose profiles showed a significant difference between the two groups. On day 7, the intra-day variation was larger in the IDeg group than in the IGla group. The incidence of hypoglycemia or glucose variability was comparable in the two groups. This study suggests that short-term efficacy and safety of IDeg and IGla in patients with type 2 diabetes during the initial phase of basal-bolus therapy were comparable, and these results can help in deciding which treatment to opt for. |
| Databáze: | OpenAIRE |
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