Severe refractory thrombocytopenia in a woman positive for coronavirus disease 2019 with lupus and antiphospholipid syndrome

Autor:	Alina Hayden, Alla Rudinskaya, Aishwarya Vyas-Lahar, Vincent Rella
Rok vydání:	2020
Předmět:	Pediatrics medicine.medical_specialty Pneumonia Viral Eltrombopag 030204 cardiovascular system & hematology Betacoronavirus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Antiphospholipid syndrome Pandemic Humans Lupus Erythematosus Systemic Medicine Platelet Refractory Thrombocytopenia Pandemics 030203 arthritis & rheumatology Systemic lupus erythematosus biology SARS-CoV-2 business.industry COVID-19 Middle Aged Antiphospholipid Syndrome medicine.disease Thrombocytopenia Platelet transfusion chemistry biology.protein Female Antibody Coronavirus Infections business
Zdroj:	Lupus. 29:1472-1474
ISSN:	1477-0962 0961-2033
DOI:	10.1177/0961203320940389
Popis:	The coronavirus disease 2019 (COVID-19) pandemic has created new challenges that necessitate prompt responses in unexpected clinical situations. Multiple extrapulmonary manifestations and complications of COVID-19 have already been described, but only scattered data are present on immunologic manifestations. We present a case of severe refractory thrombocytopenia in a 51-year-old woman with a history of long-standing systemic lupus erythematosus and antiphospholipid syndrome who presented with hemoptysis in the setting of COVID-19 infection. The patient failed to respond to initial treatment with intravenous immunoglobulin, high-dose steroids, and platelet transfusion, but responded to eltrombopag, with prompt improvement of a platelet count. The current case report provides clinical data of relevance to the largely unexplored question of the immunologic complications of COVID-19 in patients with a pre-existing inflammatory state.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafd7137364190f60fa51946e9ec702e https://doi.org/10.1177/0961203320940389 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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