Galectin-3 and Aldosterone as Potential Tandem Biomarkers in Pulmonary Arterial Hypertension
| Autor: | Johann Bauersachs, Christoph Schroeder, Laurent Calvier, Brian D. Plouffe, Lena Grimm, Shashi K. Murthy, Georg Hansmann, Adam Hatch, Ekaterina Legchenko, Hannes Sallmon |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Galectin 3 Disease 030204 cardiovascular system & hematology Severity of Illness Index Meso scale chemistry.chemical_compound 0302 clinical medicine Natriuretic Peptide Brain Natriuretic peptide Aldosterone Blood Proteins Middle Aged Prognosis Connective tissue disease Up-Regulation Galectin-3 Female Functional status Inflammation Mediators Cardiology and Cardiovascular Medicine Adult Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.drug_class Galectins Hypertension Pulmonary Enzyme-Linked Immunosorbent Assay Article 03 medical and health sciences Disease severity Predictive Value of Tests Internal medicine Severity of illness medicine Humans Aged business.industry Case-control study medicine.disease Pulmonary hypertension Peptide Fragments Circulating biomarkers 030104 developmental biology Endocrinology chemistry Case-Control Studies Surgery business Biomarkers |
| Zdroj: | The Thoracic and Cardiovascular Surgeon. 64 |
| ISSN: | 1439-1902 0171-6425 |
| DOI: | 10.1055/s-0036-1571946 |
| Popis: | Several studies have identified circulating biomarkers to be associated with the presence and severity of pulmonary arterial hypertension (PAH). Recent evidence supports a role for galectin-3 (Gal-3) and the mineralcorticoid aldosterone in left ventricular failure. However, studies on aldosterone together with Gal-3 in PAH are lacking.We investigated a novel Aldosterone-galectin-3 (Gal-3) tandem and several other potential PAH biomarkers and their association with the disease severity.A total of 57 patients, 41 with idiopathic PAH. (IPAH) and 16 with PAH associated with connective tissue disease (CTD), and 8 age-matched, non-relative controls were studied. Gal-3, aldosterone and other potential protein plasma concentrations were measured by single ELISA and multi-array MSD (Meso Scale Discovery) technology.Gal-3 values were increased in both patients with IPAH (12.2±0.6 ng/mL; p0.05) and with PAH-CTD (14.1±1.6 ng/mL; p0.05) versus control (8.5±0.9 ng/mL), while aldosterone was significantly elevated in IPAH only (248.5±38.8 pg/mL vs control 71.9±18.2 pg/mL; p0.05). In addition, aldosterone, Gal-3, and N-terminal pro-brain natriuretic peptide (NT-proBNP) values were all higher in patients in WHO functional class II-III versus PAH functional class I or controls. The vascular injury marker intercellular adhesion molecule 1 (ICAM-1) was increased in IPAH and PAH-CTD versus controls (559.5±18.2 pg/mL and 734.1±59.4 pg/mL vs controls 394.8±39.3 pg/mL, p0.05, p0.0001, respectively), whereas vascular cell adhesion molecule 1 (VCAM-1) and proinflammatory, anti-angiogenic interleukin-12 (IL-12) were elevated in PAH-CTD only (879.5±110.0 pg/mL and 391.2±70.3 pg/mL vs controls 489.8±44.6 pg/mL, p0.01, and 102.1±15.2 pg/mL, p0.01, respectively).Heightened Gal-3 and aldosterone plasma concentrations in PAH patients indicate a role for Gal-3 signalling in the pathobiology of IPAH and PAH-CTD, and may serve as biomarkers for functional status and progression of disease. |
| Databáze: | OpenAIRE |
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