Expression of the cell–cell adhesion molecule E-cadherin in tongue carcinoma cell lines
| Autor: | Andrew S. Jones, G. L. Bowie, A. R. Kinsella, J. K. Fields |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pathology
medicine.medical_specialty Epithelioma business.industry Cadherin Cell adhesion molecule Fluorescent Antibody Technique General Medicine Cadherins medicine.disease In vitro Tongue Neoplasms Otorhinolaryngology Gentamicin protection assay Cell culture Tongue Carcinoma Carcinoma Squamous Cell Tumor Cells Cultured Carcinoma Cancer research Humans Medicine Neoplasm Invasiveness business |
| Zdroj: | The Journal of Laryngology & Otology. 108:957-961 |
| ISSN: | 1748-5460 0022-2151 |
| DOI: | 10.1017/s0022215100128622 |
| Popis: | A reduction in cell adhesiveness and cell invasion are essential steps in tumour progression. In the present study six tongue carcinoma cell lines were compared with regard to their invasive potential in two invitroinvasion assay systems and for their patterns of expression of the cell–cell adhesion molecule E-cadherin. The three cell lines negative for E-cadherin expression were invasive in both assays. One cell line with strong E-cadherin expression was strongly invasive and one weakly invasive. One cell line with reduced E-cadherin expression was weakly invasive. There was no significant pattern to these findings (x2= 0.375;p= 0.54). This supports previous studies from this group that suggest that E-cadherin is only one of the presumably many molecules involved in tumour progression in squamous cell carcinoma of the tongue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|