Early pregnancy protein multiplex screening reflects circulating and urinary divergences associated with the development of preeclampsia

Autor: Luis Octavio Solís-Sánchez, Idalia Garza-Veloz, Rodrigo Castañeda-Miranda, Ivan Delgado-Enciso, Claudia Castruita-De la Rosa, J. M. Ortiz-Rodriguez, Miguel A Cid-Baez, Yolanda Ortiz-Castro, Margarita L Martinez-Fierro, Angelica Garcia Aviles, Elma I Sotelo-Ham, Edith Cardenas-Vargas, Rosa M Cardiel-Hernandez, Marcela A. Espinoza-Juarez, Fabiola Trejo-Vazquez, Maria E Castañeda-Lopez
Rok vydání: 2018
Předmět:
Adult
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Fas Ligand Protein
Adolescent
Urinary system
030204 cardiovascular system & hematology
Preeclampsia
Angiopoietin-2
Young Adult
03 medical and health sciences
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Placenta
Internal Medicine
medicine
Humans
Multiplex
reproductive and urinary physiology
Placenta Growth Factor
Fetus
030219 obstetrics & reproductive medicine
Proteinuria
Hepatocyte Growth Factor
Interleukin-6
Obstetrics
business.industry
Endoglin
Obstetrics and Gynecology
Cancer
Transforming Growth Factor alpha
Prognosis
medicine.disease
female genital diseases and pregnancy complications
Prolactin
ErbB Receptors
Pregnancy Trimester
First
medicine.anatomical_structure
Case-Control Studies
Pregnancy Trimester
Second
embryonic structures
Female
medicine.symptom
business
Biomarkers
Pregnancy disorder
Zdroj: Hypertension in Pregnancy. 37:37-50
ISSN: 1525-6065
1064-1955
DOI: 10.1080/10641955.2017.1411946
Popis: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia.To evaluate the preeclampsia predictive value of 34 angiogenic-related proteins.We performed a nested cohort case-control study of pregnant women. The profile of the 34 proteins was evaluated at 12, 16, and 20 gestational weeks (GWs), using urine/plasma from 16 women who developed preeclampsia and 20 normotensive pregnant controls by Bio-Plex ProThe urine concentration of soluble epidermal growth factor receptor (sEGFR), hepatocyte growth factor (HGF), angiopoietin-2 (ANG-2), endoglin (ENG), soluble fas ligand (sFASL), interleukin 6 (IL-6), placental growth factor (PLGF), and vascular endothelial growth factor A (VEGF-A) at 12 GW, prolactin (PRL), ANG-2, transforming growth factor alpha (TGF-α), and VEGF-A at 16 GW, and soluble IL-6 receptor alpha (sIL-6Rα), ANG-2 and sFASL at 20 GW, were different between groups (p 0.05). The concentration cut-off values calculated in this study for the mentioned proteins, predicted an increased risk to developing preeclampsia in a range of 3.8-29.8 times in the study population.The proteins sEGFR, HGF, ANG-2, sFASL, IL-6, PLGF, VEGF-A, PRL, TGF-α FGF-b, sHER2/Neu sIL-6Rα, ENG, uPA, and insulin-like growth factor binding protein 1 (IGFBP-1), were predictive of the development of preeclampsia and their use as markers for this disease should be considered.
Databáze: OpenAIRE
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