Spectroscopic Characterization and Biological Activity of Mixed Ligand Complexes of Ni(II) with 1,10-Phenanthroline and Heterocyclic Schiff Bases
| Autor: | Vijay Kumar Chityala, K. Kiranmai, Shivaraj, Y. Prashanthi, Ira, Sathish kumar K |
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| Rok vydání: | 2012 |
| Předmět: |
Thermogravimetric analysis
Denticity Article Subject Chemistry Stereochemistry lcsh:Biotechnology Monobasic acid Phenanthroline Organic Chemistry Biochemistry Binding constant lcsh:QD146-197 Inorganic Chemistry Metal chemistry.chemical_compound lcsh:TP248.13-248.65 visual_art Polymer chemistry Octahedral molecular geometry lcsh:Inorganic chemistry visual_art.visual_art_medium Chelation Research Article |
| Zdroj: | Bioinorganic Chemistry and Applications Bioinorganic Chemistry and Applications, Vol 2012 (2012) |
| ISSN: | 1687-479X 1565-3633 |
| DOI: | 10.1155/2012/948534 |
| Popis: | Mixed ligand complexes of Ni(II) with 1,10-phenanthroline (1,10-Phen) and Schiff bases L1(MIIMP); L2(CMIIMP); L3(EMIIMP); L4(MIIMNP); L5(MEMIIMP); L6(BMIIMP); L7(MMIIMP); L8(MIIBD) have been synthesized. These metal chelates have been characterized by elemental analysis, IR,1H-NMR,13C-NMR, Mass, UV-Vis, magnetic moments, and thermogravimetric (TG&DTA) analysis. Spectral data showed that the 1,10-phenanthroline act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms and Schiff bases acts as monobasic bidentate coordinating through NO donor atoms. All Ni(II) complexes appear to have an octahedral geometry. The antimicrobial activity of mixed ligand complexes has been studied by screening against various microorganisms, it is observed that the activity enhances upon coordination. The DNA binding studies have been investigated by UV-Vis spectroscopy, and the experimental results indicate that these complexes bind to CT DNA with the intrinsic binding constantKb=2.5±0.2×105 M−1. MTT is used to test the anticancer effect of the complexes with HL60 tumor cell. The inhibition ratio was accelerated by increasing the dosage, and it had significant positive correlation with the medication dosage. |
| Databáze: | OpenAIRE |
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