Childhood Adiposity Associated With Expanded Effector Memory CD8+ and Vδ2+Vγ9+ T Cells
| Autor: | Trudy Voortman, Vincent V. W. Jaddoe, Charlotte W E Leijten, Menno C. van Zelm, Henriëtte A. Moll, Kirsten I M Looman, Jessica C. Kiefte-de Jong, Christina Grosserichter-Wagener, Susana Santos |
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| Přispěvatelé: | Pediatrics, Immunology, Epidemiology |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatric Obesity medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Context (language use) Inflammation CD8-Positive T-Lymphocytes Biochemistry Monocytes Immunophenotyping Cohort Studies Endocrinology Immune system SDG 3 - Good Health and Well-being Internal medicine medicine Humans Lymphocyte Count Child Gamma delta T cell education Adiposity Netherlands 2. Zero hunger education.field_of_study business.industry Biochemistry (medical) Genes T-Cell Receptor gamma Lymphocyte Subsets Cross-Sectional Studies medicine.anatomical_structure Female medicine.symptom business Immunologic Memory CD8 Genes T-Cell Receptor delta Blood sampling |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 106(10), E3923-E3935. Endocrine Society |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/clinem/dgab433 |
| Popis: | ContextAdult obesity is associated with chronic low-grade inflammation and may give rise to future chronic disease. However, it is unclear whether adiposity-related inflammation is already apparent in childhood.ObjectiveTo study associations between child adiposity measures with circulating monocytes and naive and memory subsets in CD4, CD8, and γδ T cell lineages.MethodsTen-year-old children (n = 890) from the Generation R Cohort underwent dual-energy x-ray absorptiometry and magnetic resonance imaging for body composition (body mass index [BMI], fat mass index [FMI], android-to-gynoid fat mass ratio, visceral fat index, liver fat fraction). Blood samples were taken for detailed immunophenotyping of leukocytes by 11-color flow cytometry.ResultsSeveral statistically significant associations were observed. A 1-SD increase in total FMI was associated with +8.4% (95% CI 2.0, 15.2) Vδ2+Vγ9+ and +7.4% (95% CI 2.4, 12.5) CD8+TEMRO cell numbers. A 1-SD increase in visceral fat index was associated with +10.7% (95% CI 3.3, 18.7) Vδ2+Vγ9+ and +8.3% (95% CI 2.6, 14.4) CD8+TEMRO cell numbers. Higher android-to-gynoid fat mass ratio was only associated with higher Vδ2+Vγ9+ T cells. Liver fat was associated with higher CD8+TEMRO cells but not with Vδ2+Vγ9+ T cells. Only liver fat was associated with lower Th17 cell numbers: a 1-SD increase was associated with −8.9% (95% CI −13.7, −3.7) Th17 cells. No associations for total CD8+, CD4+ T cells, or monocytes were observed. BMI was not associated with immune cells.ConclusionHigher Vδ2+Vγ9+ and CD8+TEMRO cell numbers in children with higher visceral fat index could reflect presence of adiposity-related inflammation in children with adiposity of a general population. |
| Databáze: | OpenAIRE |
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