Filling the holes in cystic kidney disease research
| Autor: | Peter Igarashi, Michael F. Flessner, Lisa M. Guay-Woodford, Vicente E. Torres, Ronald D. Perrone, Stefan Somlo, Elizabeth P. Henske, Christian J. Ketchum, Rebekah S. Rasooly, Berenice Reed-Gitomer, Robert A. Star |
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| Rok vydání: | 2014 |
| Předmět: |
Genetic Markers
medicine.medical_specialty Pathology Biomedical Research Epidemiology Renal function Critical Care and Intensive Care Medicine Risk Assessment Cystic kidney disease Predictive Value of Tests Risk Factors Diabetes mellitus medicine Polycystic kidney disease Animals Humans Genetic Predisposition to Disease Intensive care medicine Cystic diseases Cystic kidney Transplantation Polycystic Kidney Diseases business.industry urogenital system Health Priorities Public health medicine.disease Prognosis Special Features Phenotype Nephrology Diffusion of Innovation business Kidney disease |
| Zdroj: | Clinical journal of the American Society of Nephrology : CJASN. 9(10) |
| ISSN: | 1555-905X |
| Popis: | Kidney disease is a significant medical and public health problem. The National Institute of Diabetes and Digestive and Kidney Diseases recently asked the community to identify research objectives, which, if addressed, could improve understanding of basic kidney function and aid in prevention, treatment, and reversal of kidney disease. The Kidney Research National Dialogue invited interested parties to submit, discuss, and prioritize ideas using an interactive website; 1600 participants posted more than 300 ideas covering all areas of kidney disease, including the cystic kidney diseases. Although much is known about the genetics and pathogenesis of cystic diseases, there remain challenges to our understanding of the fundamental mechanisms of cyst formation, what genes act as modifiers to cause variable responses in different people, and how to detect and monitor disease progression. This article summarizes key research questions for cystic kidney diseases. |
| Databáze: | OpenAIRE |
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