Platanic Acid‐Aryl Enones as Potential Anticancer Compounds: Synthesis and Biological Profiling against Breast, Prostate and Lung Cancer Cell Lines
| Autor: | Tabassum Ara, Bilal A. Bhat, Auqib Rashid, Mir Shahid, Javid A. Banday, Fayaz Malik, Bilal Ahmad Ganaie |
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| Rok vydání: | 2021 |
| Předmět: |
Cell Survival
Antineoplastic Agents Bioengineering Biochemistry Structure-Activity Relationship chemistry.chemical_compound Prostate Cell Line Tumor Betulinic acid medicine Humans MTT assay Cytotoxicity Molecular Biology Platanic acid Cell Proliferation Dose-Response Relationship Drug Molecular Structure Aryl General Chemistry General Medicine Ketones Triterpenes medicine.anatomical_structure chemistry Cell culture Molecular Medicine Aldol condensation Drug Screening Assays Antitumor |
| Zdroj: | Chemistry & Biodiversity. 18 |
| ISSN: | 1612-1880 1612-1872 |
| DOI: | 10.1002/cbdv.202100292 |
| Popis: | A series of rationally designed platanic acid-based compounds derived from naturally occurring betulinic acid were synthesized through a sequence of Lemieux-Johnson oxidation and Aldol condensation reaction. All the compounds were screened for cytotoxicity against a panel of human cancer and normal cell lines using MTT assay. From the biological data, it was observed that some of these semi-synthetic congeners exhibited potent biological profiles compared to platanic acid. One of the compounds with the p-tolyl substitution was found to be most active in this study, and its cytotoxicity against two of the cell lines, MDA-MB 231 and A-549 were in tune with the standard compound, 5-fluorouracil. |
| Databáze: | OpenAIRE |
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