Digoxin infusion versus bolus injection in rapid atrial fibrillation

Autor: Kong I. Lie, L. H. Van Essen, Andries J. Smit, Harry Wesseling, A. H. J. Scaf
Jazyk: angličtina
Rok vydání: 1990
Předmět:
Zdroj: European Journal of Clinical Pharmacology, 38(4), 335-341. Springer Verlag
ISSN: 1432-1041
0031-6970
DOI: 10.1007/BF00315571
Popis: Using available data on time-concentration and time-effect relationships in normal persons the results of infusion of digoxin in various time periods were simulated and compared with administration of digoxin by bolus injections, using a three-compartment pharmacokinetic model to which a separate small side-effect compartment was subsequently added. The validity of the simulations was tested in 11 patients with rapid atrial fibrillation. Serum digoxin concentrations, ventricular rate and side effects were monitored in a double-blind study comparing an infusion of 1.5 mg digoxin over 6 h with administration of three bolus injections of 0.5 mg digoxin 8 h apart.In agreement with the predictions of the model, the maximal fall in ventricular rate was reached after 8–9 h in the infusion group and after 19–20 h in the bolus injection group, without any detectable difference in side effects.There were certain discrepancies between the results of the clinical study and the predictions of the model, e.g. in serum digoxin concentrations, perhaps due to impaired clearance in the patients.However, it is concluded that the tested model is valid in elderly patients with rapid atrial fibrillation.
Databáze: OpenAIRE
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