The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study
| Autor: | Jan Schepers, Madelon L. Peters, Monique R. T. M. Thissen, Wim A. Buurman, Hugo J. E. M. Alberts, Chantal A. H. Weijzen, Mario Losen, Astrid Meesters, Casper G. Schalkwijk, Yvo M. C. In den Bosch-Meevissen |
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| Přispěvatelé: | Section Experimental Health Psychology, RS: FPN CPS I, Section Clinical Psychology, Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, FPN Methodologie & Statistiek, RS: FPN M&S I, Dermatologie, MUMC+: MA Dermatologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Interne Geneeskunde, RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Placental growth factor Time Factors Mindfulness medicine.medical_treatment Inflammation Permeability Mindfulness-based stress reduction Young Adult 03 medical and health sciences 0302 clinical medicine Journal Article medicine Humans General Psychology Placenta Growth Factor Wound Healing Vascular Endothelial Growth Factor Receptor-1 integumentary system business.industry Interleukin-8 Interleukin 030227 psychiatry Suction blister Psychiatry and Mental health Treatment Outcome Cytokine Anesthesia Cytokines Female medicine.symptom Wound healing business Biomarkers Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Journal of Behavioral Medicine, 41(3), 385-397. Springer |
| ISSN: | 1573-3521 0160-7715 |
| DOI: | 10.1007/s10865-017-9901-8 |
| Popis: | Psychological factors have been shown to influence the process of wound healing. This study examined the effect of Mindfulness-Based Stress Reduction (MBSR) on the speed of wound healing. The local production of pro-inflammatory cytokines and growth factors was studied as potential underlying mechanism. Forty-nine adults were randomly allocated to a waiting-list control group (n = 26) or an 8-week MBSR group (n = 23). Pre- and post-intervention/waiting period assessment for both groups consisted of questionnaires. Standardized skin wounds were induced on the forearm using a suction blister method. Primary outcomes were skin permeability and reduction in wound size monitored once a day at day 3, 4, 5, 6, 7, and 10 after injury. Secondary outcomes were cytokines and growth factors and were measured in wound exudates obtained at 3, 6, and 22 h after wounding. Although there was no overall condition effect on skin permeability or wound size, post hoc analyses indicated that larger increases in mindfulness were related to greater reductions in skin permeability 3 and 4 days after wound induction. In addition, MBSR was associated with lower levels of interleukin (IL)-8 and placental growth factor in the wound fluid 22 h after wound induction. These outcomes suggest that increasing mindfulness by MBSR might have beneficial effects on early stages of wound healing. Trial Registration NTR3652, http://www.trialregister.nl |
| Databáze: | OpenAIRE |
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