Management of tuberculosis and HIV co-infection in Cotonou, Benin
| Autor: | Séverin Anagonou, Dissou Affolabi, Serge Ade, G. Ade, G. Agodokpessi, M. Gninafon, A.P. Wachinou |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Tuberculosis Adolescent Anti-HIV Agents Cross-sectional study Antitubercular Agents HIV Infections Comorbidity Mycobacterium tuberculosis Young Adult Acquired immunodeficiency syndrome (AIDS) Trimethoprim Sulfamethoxazole Drug Combination Prevalence Benin Humans Mass Screening Medicine Mass screening Aged Retrospective Studies Aged 80 and over AIDS-Related Opportunistic Infections biology business.industry Mortality rate Sputum Disease Management Retrospective cohort study Middle Aged biology.organism_classification medicine.disease CD4 Lymphocyte Count Cross-Sectional Studies Treatment Outcome Infectious Diseases Immunology Drug Therapy Combination Female medicine.symptom business |
| Zdroj: | Médecine et Maladies Infectieuses. 42:561-566 |
| ISSN: | 0399-077X |
| Popis: | The authors had for aim to assess the management of tuberculosis and HIV co-infection in Cotonou, Benin.We made a cross-sectional, retrospective, and descriptive study comparing the clinical presentation and outcome of patients with tuberculosis and HIV co-infection versus patients with tuberculosis alone, all managed at the National Pneumophtisiology Center in Cotonou, Benin, in 2009.The rate of HIV screening in TB patients was 99%. One thousand and eighty-six TB patients were included and 259 were HIV positive. The mean age of co-infected patients was 36 years, versus 34 for TB mono-infected patients. The sex ratio among co-infected was 1.15 versus 2.25 among TB patients. Positive pulmonary sputum was less frequent with co-infection. Two hundred and fifty-seven over 259 patients were treated with cotrimoxazole. One hundred and eighty-five over 234 (79.05%) had CD4 counts350. Eighty-five (46%) of the 185 patients with CD4350, were given antiretroviral therapy. Treatment success rate was lower for co-infected (75%) than for patients with TB alone (86%), and death rates were higher in co-infected patients (10% vs. 3%).High death rate and high rate of lost to follow-up are arguments for systematic antiretroviral treatment of co-infected patients. Early screening for TB and HIV, and reviewing the current national recommendations, as well as an increased governmental effort to provide medicines to all patients in need of ARV are mandatory. |
| Databáze: | OpenAIRE |
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