From genomes to diaries: a 3-year prospective, real-life study of ragweed-specific sublingual immunotherapy
| Autor: | Lilla Tamási, Adrienne Nagy, Andras Bikov, Györgyi Zsigmond, Ibolya Czaller, Anita Farkas, Gergely Tibor Kozma, Beáta Fábos, Zsuzsanna Csoma, Maria Sasvari-Szekely, Edina Kurucz, Balint L. Balint, Zsofia Gal, Csaba Szalai, Eszter Kotyuk, Péter Antal, Gabriella Gálffy, Anikó Kurucz, Viktor Molnár, Zoltán Csontos, Magdolna Krasznai, András Gézsi, Anna Szekely, Gábor Cserta, Renata Bocskei, András Millinghoffer, Csilla Csáki |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Ragweed medicine.medical_specialty Immunology Clinical Decision-Making Patient diary Disease Medical Records 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) medicine Hypersensitivity Immunology and Allergy Humans Patient Reported Outcome Measures Prospective Studies Precision Medicine Intensive care medicine Electronic Data Processing Sublingual Immunotherapy Genome biology business.industry Medical record Data Collection Allergens Antigens Plant Precision medicine biology.organism_classification 030104 developmental biology Phenotype 030228 respiratory system Oncology Observational study Personalized medicine Ambrosia business |
| Zdroj: | Immunotherapy. 9(15) |
| ISSN: | 1750-7448 |
| Popis: | During the last decades, the prevalence of allergy has dramatically increased. Allergen-specific immunotherapy is the only currently available medical intervention that has the potential to affect the natural course of the disease, but there are still many questions and unmet needs hindering its widespread use to fulfill its treatment potential and maximize its benefits for the society. To provide a comprehensive phenome-wide overview in sublingual immunotherapy, using ragweed allergy as a target, we planned and carried out a longitudinal, prospective, observational, open-label study (DesensIT). In this paper we present challenges of using deep and comprehensive phenotypes embracing biological, clinical and patient-reported outcomes in allergen-specific immunotherapy and show how we designed the DesensIT project to optimize data collection, processing and evaluation. |
| Databáze: | OpenAIRE |
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