Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness

Autor: Doaa Rayan, Eyal Sela, Michael Edelstein, Amani Daoud, Yoav Namir, Mark Lifshitz, Maayan Gruber, Amir Bashkin, Yakir Orly, Lior Fischer, Yair Shachar, Edward Kaykov, Matti Mizrachi, Masad Barhoum, Ella Segal, Amiel A. Dror, Netanel Eisenbach, Nicole G. Morozov
Rok vydání: 2021
Předmět:
Male
Viral Diseases
Arabic People
Pulmonology
Epidemiology
Organic chemistry
Comorbidity
Disease
Severity of Illness Index
Medical Conditions
Patient Admission
Risk Factors
Medicine and Health Sciences
Ethnicities
Vitamin D
Israel
Virus Testing
Aged
80 and over
COPD
Multidisciplinary
Vitamins
Middle Aged
Prognosis
Physical sciences
Chemistry
Infectious Diseases
Nutritional deficiencies
Medicine
Female
Research Article
Adult
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Science
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vitamin D deficiency
Ethnic Epidemiology
Chemical compounds
Respiratory Disorders
Diagnostic Medicine
Diabetes mellitus
Internal medicine
Organic compounds
medicine
Vitamin D and neurology
Humans
Nutrition
Aged
Retrospective Studies
Vitamin D deficiency
Biology and life sciences
SARS-CoV-2
business.industry
COVID-19
Covid 19
Retrospective cohort study
medicine.disease
Medical Risk Factors
People and Places
Respiratory Infections
Population Groupings
business
Zdroj: PLoS ONE, Vol 17, Iss 2, p e0263069 (2022)
PLoS ONE
Popis: Objective Studies have demonstrated a potential correlation between low vitamin D status and both an increased risk of infection with SARS-CoV-2 and poorer clinical outcomes. This retrospective study examines if, and to what degree, a relationship exists between pre-infection serum 25-hydroxyvitamin D (25(OH)D) level and disease severity and mortality due to SARS-CoV-2. Participants The records of individuals admitted between April 7th, 2020 and February 4th, 2021 to the Galilee Medical Center (GMC) in Nahariya, Israel, with positive polymerase chain reaction (PCR) tests for SARS-CoV-2 (COVID-19) were searched for historical 25(OH)D levels measured 14 to 730 days prior to the positive PCR test. Design Patients admitted to GMC with COVID-19 were categorized according to disease severity and level of 25(OH)D. An association between pre-infection 25(OH)D levels, divided between four categories (deficient, insufficient, adequate, and high-normal), and COVID-19 severity was ascertained utilizing a multivariable regression analysis. To isolate the possible influence of the sinusoidal pattern of seasonal 25(OH)D changes throughout the year, a cosinor model was used. Results Of 1176 patients admitted, 253 had records of a 25(OH)D level prior to COVID-19 infection. A lower vitamin D status was more common in patients with the severe or critical disease (p < 0.001). Patients with vitamin D deficiency (p < 0.001). Conclusions Among hospitalized COVID-19 patients, pre-infection deficiency of vitamin D was associated with increased disease severity and mortality.
Databáze: OpenAIRE
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