Detection and staging of preinvasive lesions and occult lung cancer in the central airways with 18F-fluorodeoxyglucose positron emission tomography: a pilot study
| Autor: | Tom G. Sutedja, Elle K.J. Risse, Arifa Pasic, Hes A.P. Brokx, Otto S. Hoekstra, Emile F.I. Comans, Pieter E. Postmus, Gerarda J.M. Herder |
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| Přispěvatelé: | VU University medical center |
| Rok vydání: | 2005 |
| Předmět: |
Male
Cancer Research Lung Neoplasms Pilot Projects Sensitivity and Specificity Lesion Fluorodeoxyglucose F18 Positive predicative value Bronchoscopy medicine Humans Neoplasms Squamous Cell Prospective Studies Lung cancer Aged Neoplasm Staging medicine.diagnostic_test business.industry Micrometastasis Respiratory disease Middle Aged medicine.disease Occult Confidence interval Oncology Positron emission tomography Lymphatic Metastasis Positron-Emission Tomography Female medicine.symptom Radiopharmaceuticals Nuclear medicine business |
| Zdroj: | Clinical Cancer Research, 11(17), 6186-6189. American Association for Cancer Research Inc. Pasic, A, Brokx, HA, Comans, E F I, Herder, GJ, Risse, EK, Hoekstra, O S, Postmus, P E & Sutedja, T G 2005, ' Detection and staging of preinvasive lesions and occult lung cancer in the central airways with 18F-fluorodeoxyglucose positron emission tomography: a pilot study ', Clinical Cancer Research, vol. 11, no. 17, pp. 6186-6189 . https://doi.org/10.1158/1078-0432.CCR-04-2480 |
| ISSN: | 1078-0432 |
| Popis: | Purpose: To evaluate the role of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in radiologically occult preinvasive lesions and lung cancer in the central airways.Experimental Design: Twenty-two patients with 24 preinvasive lesions and early squamous cell cancer (SCC) being occult on high-resolution computed tomography were studied. All lesions were diagnosed based on histology sampled using autofluorescence bronchoscopy. FDG-PET findings were correlated with WHO histologic classification. FDG-PET was considered true-positive when the final diagnosis was SCC and true-negative when the lesions were classified as severe dysplasia or less.Results: FDG-PET was true-positive in 8 of 11 and true-negative in 11 of 13 cases corresponding with a sensitivity of 73% [95% confidence interval (CI), 0.43-0.91] and specificity of 85% (95% CI, 0.57-0.97). Positive and negative predictive values were 80% (95% CI, 0.48-0.96) and 79% (95% CI, 0.52-0.93), respectively.Conclusions: Our very preliminary data suggest that FDG-PET might be useful for the evaluation of early central airway lesions, being positive in most SCC and negative in cases of severe dysplasia. Validation in a larger multicenter study is needed. |
| Databáze: | OpenAIRE |
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