Controlled mechanotransduction in therapeutic MSCs: can remotely controlled magnetic nanoparticles regenerate bones?
| Autor: | Alicia J. El Haj, James R. Henstock |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Embryology
Cell biomechanics medicine.medical_treatment Mesenchymal stem cell Cell Biomedical Engineering Mesenchymal Stem Cells Stem-cell therapy Anatomy Biology Mechanotransduction Cellular Regenerative medicine Bone and Bones Biomechanical Phenomena Translational Research Biomedical medicine.anatomical_structure medicine Humans Intercellular Signaling Peptides and Proteins Regeneration Mechanotransduction Signal transduction Magnetite Nanoparticles Neuroscience Tissue homeostasis |
| Zdroj: | Regenerative Medicine. 10:377-380 |
| ISSN: | 1746-076X 1746-0751 |
| Popis: | Mechanotransduction, the conversion of the external, environmental forces acting on a cell into internal biochemical signaling pathway, is now becoming a recognized route for delivering tissue-forming stimuli to therapeutic cells. In the body, complex loading forces transduced through tissue serve to inform cells of their physical environment and can therefore have profound effects on tissue homeostasis, regulating many aspects of cell behavior including proliferation, differentiation and ECM composition [1–4]. With this growing awareness of the role of cell biomechanics, several researchers have now started to focus their attention on exploiting these biomechanical pathways to resolve long-standing challenges in regenerative medicine – the optimal construction, repair and integration of tissues in the body. |
| Databáze: | OpenAIRE |
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