Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease
| Autor: | Fu Huang Lin, Wei Teing Chen, Sui-Lung Su, Shih Jen Yeh, Chin Lin, Hung Chang, Yuh Feng Lin, Kuo Cheng Lu, Po-Jen Hsiao, Wen Su |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Angiotensin receptor Angiotensin II receptor type 1 business.industry Single-nucleotide polymorphism renin-angiotensin system Odds ratio medicine.disease Gastroenterology Confidence interval polymorphism 03 medical and health sciences 030104 developmental biology Oncology Internal medicine Genotype medicine Allele business chronic kidney disease Kidney disease Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Single nucleotide polymorphisms (SNPs) in renin-angiotensin system (RAS) genes are associated with RAS imbalance and chronic kidney disease (CKD). We performed a case-control study and meta-analysis to investigate the association between angiotensinogen (AGT) M235T polymorphism and CKD. A total of 634 patients with end-stage renal disease and 739 healthy controls were studied. We also searched PubMed and the Cochrane Library to identify prospective observational studies published before December 2015. We found that the TT and MT genotypes were associated with a higher risk of CKD than the MM genotype (odds ratio [OR]: 3.56; 95% confidence interval [CI]: 1.14-11.16 and OR: 2.93; 95% CI: 0.91-9.46, respectively). Thirty-eight study populations were included in the meta-analysis. The T allele was associated with a higher risk of CKD than the M allele in all populations (OR: 1.19; 95% CI: 1.08-1.32). The OR was 1.33 in Asians (95% CI: 1.06-1.67) and 1.10 in Caucasians (95% CI: 1.02-1.18). Evaluation of gene-gene and gene-environment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% CI: 0.609-0.965). Genetic testing for CKD in high-risk individuals may be an effective strategy for CKD prevention. |
| Databáze: | OpenAIRE |
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