Supplement-based nutritional strategies to tackle frailty: A multifactorial, double-blind, randomized placebo-controlled trial
| Autor: | Ana Lúcia de Sá-Pinto, Rosa Maria Rodrigues Pereira, Bruno Gualano, Fernanda Rodrigues Lima, José Claudio Jambassi-Filho, Hamilton Roschel, Ana Paula Hayashi, Alan Lins Fernandes, Alberto José da Silva Duarte, Mariana Dutilh de Capitani, Marcelo Tatit Sapienza, Stuart M. Phillips, Lívia de Souza Gonçalves, Davi Alves de Santana, Victoria Hevia-Larraín |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Sarcopenia Frail Elderly Frailty syndrome Placebo-controlled study Critical Care and Intensive Care Medicine Creatine Placebo chemistry.chemical_compound Sex Factors Double-Blind Method Leucine Internal medicine Medicine Humans Muscle Skeletal Wasting Aged Nutrition and Dietetics Frailty business.industry Resistance Training medicine.disease Adaptation Physiological Clinical trial Whey Proteins chemistry Dietary Supplements Lean body mass Quality of Life Soybean Proteins Female medicine.symptom business Brazil |
| Zdroj: | Clinical nutrition (Edinburgh, Scotland). 40(8) |
| ISSN: | 1532-1983 |
| Popis: | Summary Background Sarcopenia plays a central role in the development of frailty syndrome. Nutrition and exercise are cornerstone strategies to mitigate the transition to frailty; however, there is a paucity of evidence for which dietary and exercise strategies are effective. Objective This large, multifactorial trial investigated the efficacy of different dietary strategies to enhance the adaptations to resistance training in pre-frail and frail elderly. Methods This was a single-site 16-week, double-blind, randomized, placebo-controlled trial conducted at the Clinical Hospital, School of Medicine - University of Sao Paulo, Sao Paulo, Brazil. Four integrated, sub-investigations were conducted to compare: 1) leucine vs. placebo; 2) whey vs. soy vs. placebo; 3) creatine vs. whey vs. creatine plus whey vs. placebo; 4) women vs. men in response to whey. Sub-investigations 1 to 3 were conducted in women, only. Two-hundred participants (154 women/46 men, mean age 72 ± 6 years) underwent a twice-a-week, resistance training program. The main outcomes were muscle function (assessed by dynamic and isometric strength and functional tests) and lean mass (assessed by DXA). Muscle cross-sectional area, health-related quality of life, bone and fat mass, and biochemical markers were also assessed. Results We observed that leucine supplementation was ineffective to improve muscle mass and function. Supplementation with whey and soy failed to enhance resistance-training effects. Similarly, supplementation with neither whey nor creatine potentiated the adaptations to resistance training. Finally, no sex-based differences were found in response to whey supplementation. Resistance exercise per se increased muscle mass and function in all sub-investigations. There were no adverse effects. Conclusion Neither protein (whey and soy), leucine, nor creatine supplementation enhanced resistance training-induced adaptations in pre-frail and frail elderly, regardless of sex. These findings do not support the notion that some widely used supplement-based interventions can add to the already potent effects of resistance exercise to counteract frailty-related muscle wasting and dynapenia. Clinical trial registry NCT01890382; https://clinicaltrials.gov/ct2/show/NCT01890382 . Data sharing Data described in the manuscript will be made available upon request pending application. |
| Databáze: | OpenAIRE |
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